脳腫瘍細胞は 機能的で抵抗性のあるネットワークに 相互接続する
Matthias Osswald1,2, Erik Jung1,2, Felix Sahm3,4
1Neurology Clinic and National Center for Tumor Diseases, University Hospital Heidelberg, INF 400, 69120 Heidelberg, Germany.
Nature
|November 5, 2015
まとめ
アストロサイトマの脳腫瘍は 腫瘍のマイクロチューブを使って ネットワークを形成します これらのネットワークの破壊は,アストロサイトマの治療抵抗を克服する可能性があります.
科学分野:
- 神経腫瘍学
- 細胞生物学
- 癌 研究
背景:
- グリオブラストーマのような 星球細胞性脳腫瘍は 攻撃的で浸透性があります
- 現在の治療法は 腫瘍の耐性や広がりによって 困難に直面しています
研究 の 目的:
- アストロサイトマの進行における超長膜突起の役割を調査する.
- これらの構造を標的として 治療上の利点を探求する.
主な方法:
- 腫瘍細胞の突起 (腫瘍マイクロチューブ) を視覚化するための顕微鏡検査
- 細胞間通信とネットワーク形成の分析
- 侵入,拡散,放射線抵抗に対するマイクロチューブの影響の評価.
- ニューロンの成長に関連したタンパク質43 (GAP-43) の役割を調査する.
主要な成果:
- アストロサイトマ細胞は超長腫瘍マイクロチューブを形成し,侵入,増殖,長距離の相互接続を可能にします.
- これらのネットワークは,ギャップ・ジャンクションを介して多細胞通信を容易にし,ネットワークの修復を可能にします.
- マイクロチューブに接続された細胞は放射線抵抗を示しますが,接続されていない細胞はそうではありません.
- ニューロンの成長に関連するタンパク質43 (GAP-43) はマイクロチューブの形成と機能に不可欠です.
- オリゴデンドログリア腫瘍にはこのマイクロチューブベースのネットワークメカニズムがない.
結論:
- 腫瘍マイクロチューブを通して 機能的な多細胞ネットワークを形成します
- これらの腫瘍のマイクロチューブを標的と切り離すことは,アストロサイトマの治療抵抗と戦うための新しい戦略です.
関連する概念動画
Protein Networks
4.7K
An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
4.7K
Adaptive Mechanisms in Cancer Cells
7.4K
Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
7.4K
Metastasis
6.8K
Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
6.8K
Cancer Stem Cells and Tumor Maintenance
6.4K
Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
6.4K
The Tumor Microenvironment
8.1K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
8.1K
Cancer
55.7K
Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
55.7K


