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関連する概念動画

T Cell Types and Functions01:24

T Cell Types and Functions

3.2K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
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B Cell Activation and Differentiation01:24

B Cell Activation and Differentiation

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The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
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Cytotoxic T Cells-mediated Immune Response01:27

Cytotoxic T Cells-mediated Immune Response

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Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
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T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

17.3K
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
17.3K
Immune Response Against Viral Pathogens01:29

Immune Response Against Viral Pathogens

2.5K
The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
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Updated: Mar 29, 2026

Author Spotlight: Achieving High-Purity In Vitro Differentiation of Th17 Cells Using Cytokine Concentration Modulation
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Author Spotlight: Achieving High-Purity In Vitro Differentiation of Th17 Cells Using Cytokine Concentration Modulation

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Th17 病原性に対する代謝スイッチ

Fred P Davis1, Yuka Kanno1, John J O'Shea1

  • 1Molecular Immunology and Inflammation Branch, NIAMS, National Institutes of Health, Bethesda, MD 20892, USA.

Cell
|December 7, 2015
PubMed
まとめ
この要約は機械生成です。

Tヘルパー17 (Th17) 細胞は免疫と自己免疫において二重の役割を果たします. 研究によると,CD5Lは,脂質合成経路を調節することにより,Th17細胞における炎症性遺伝子発現に影響を与える.

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Retroviral CRISPR/Cas9-Mediated Gene Targeting for the Study of Th17 Differentiation in Vitro
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Isolation and Th17 Differentiation of Na&#239;ve CD4 T Lymphocytes
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Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes

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関連する実験動画

Last Updated: Mar 29, 2026

Author Spotlight: Achieving High-Purity In Vitro Differentiation of Th17 Cells Using Cytokine Concentration Modulation
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Author Spotlight: Achieving High-Purity In Vitro Differentiation of Th17 Cells Using Cytokine Concentration Modulation

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Retroviral CRISPR/Cas9-Mediated Gene Targeting for the Study of Th17 Differentiation in Vitro
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Isolation and Th17 Differentiation of Na&#239;ve CD4 T Lymphocytes
12:59

Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes

Published on: September 26, 2013

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科学分野:

  • 免疫学
  • 分子生物学
  • 遺伝学

背景:

  • Tヘルパー17 (Th17) 細胞は宿主の病原体に対する防御に不可欠です.
  • 制御不能のTh17細胞活動は,自己免疫疾患の発生に関与している.
  • Th17細胞の機能を制御する分子メカニズムを理解することは,治療的介入に不可欠です.

研究 の 目的:

  • 異なるTヘルパー17細胞の行動の 分子ドライバーを調査する.
  • Th17細胞の炎症に関連した重要な遺伝子を特定する.
  • Th17細胞媒介の炎症の調節におけるCD5Lの役割を解明する.

主な方法:

  • 約1,000個の個別のTh17細胞の単細胞遺伝子発現プロファイリング.
  • 炎症に関連した遺伝子を特定するための生物情報分析
  • Th17細胞におけるCD5L機能の実験的検証

主要な成果:

  • Th17細胞における 炎症に関連した特定の遺伝子の特定
  • CD5Lが炎症性遺伝子の発現に有意な影響を及ぼすことを示す.
  • 証拠によると,CD5LはTh17細胞内の脂質合成経路を調節することによってその効果を発揮する.

結論:

  • CD5Lは,Tヘルパー17細胞における炎症性遺伝子発現の重要なレギュラーである.
  • 変化した脂質合成は,CD5LがTh17細胞機能に影響を与えるメカニズムである.
  • これらの発見は,Th17主導の自己免疫疾患の病原性についての洞察を提供します.