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Updated: Mar 15, 2026

Detection of Alternative Splicing During Epithelial-Mesenchymal Transition
11:48

Detection of Alternative Splicing During Epithelial-Mesenchymal Transition

Published on: October 9, 2014

13.4K

細胞型特異的な代替スプライシングは,発達中の脳皮質の細胞運命を支配する

Xiaochang Zhang1, Ming Hui Chen2, Xuebing Wu3

  • 1Division of Genetics and Genomics, Manton Center for Orphan Disease Research, Howard Hughes Medical Institute, Boston Children's Hospital, Boston, MA 02115, USA; Departments of Neurology and Pediatrics, Harvard Medical School, Boston, MA 02115, USA.

Cell
|August 28, 2016
PubMed
まとめ

脳の発達過程で 細胞の運命を動的に制御します Ptbp1やRbfoxのような重要なタンパク質は,特定の遺伝子エクソンを変化させ,神経細胞の分化に影響を与え,潜在的に脳異常を引き起こします.

キーワード:
ナイネインPtbp1 についてRbfox (リボックス)フィラミンAマイクロケファリーマザー・セントリオール周縁のノードル異形

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Alternative RNA Splicing

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In eukaryotic cells, nascent mRNA transcripts need to undergo many post-transcriptional modifications to reach the cell cytoplasm and translate into functional proteins. For a long time, transcription and pre-mRNA processing were considered two independent events that occur sequentially in the cell. However, it has now been well established that transcription and pre-mRNA processing are two simultaneous processes that are precisely regulated inside the cell.
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