軸性脊椎関節炎
Joachim Sieper1, Denis Poddubnyy1
1Department of Gastroenterology, Infectious Diseases and Rheumatology, Campus Benjamin Franklin, Charité Universitätsmedizin Berlin, Berlin, Germany.
Lancet (London, England)
|January 24, 2017
まとめ
アンキロージング・スポンジライトを含む軸性脊椎関節炎は,炎症と潜在的な骨の損傷を伴う. 早期発見とTNF阻害剤やIL-17阻害剤のような治療は この状態の管理の鍵です
科学分野:
- リウマトロジ
- 免疫学
- 遺伝学
背景:
- 軸性脊椎関節炎 (AxSpA) は,放射線検査 (アンキロージング脊椎炎) と放射線検査以外の形態を含む.
- 発症は通常30代で 男性と女性の割合が異なります
- 高い遺伝性 (> 90%) は,HLA-B27と関連しているが,その病原性の役割についてはさらなる解明が必要である.
研究 の 目的:
- 軸性脊椎関節炎の病原性,診断,治療について検討する.
- 重要なサイトカインの役割と早期発見の重要性を強調する.
- 現在の治療戦略と新たな治療戦略について議論する.
主な方法:
- 臨床試験と病原性メカニズムの文献レビュー
- 遺伝子関連性,特にHLA-B27の分析
- MRIやセラピーのような 診断手段の評価
主要な成果:
- 腫瘍死因アルファ (TNF-α) とインタールイキン17 (IL-17) は,AxSpAの病原性に関与しています.
- 新しい分類とスクリーニングの基準は,MRIと共に,早期の患者の識別を助けます.
- 非ステロイド性抗炎症薬 (NSAIDs) とTNF阻害薬が有効であることが示されています.
結論:
- 炎症と骨の形成の相互作用を理解することは 長期的な損傷を防ぐために不可欠です
- IL-17の阻害は,AxSpAの治療における重要な進歩を表しています.
- IL-17阻害を含む早期診断と標的治療は,患者のアウトカムを改善します.
関連する概念動画
Overview of the Axial Skeleton
13.1K
The skeleton is subdivided into two major divisions—the axial skeleton and the appendicular skeleton. The axial skeleton forms the vertical, central axis of the body. It includes all of the bones of the head, neck, chest, and back. It protects the brain, spinal cord, heart, and lungs. It also serves as the attachment site for muscles that move the head, neck, and back and for muscles that act across the shoulder and hip joints to move their corresponding limbs.
The axial skeleton of the...
The axial skeleton of the...
13.1K
Articulations of the Vertebral Column
3.5K
In addition to being held together by the intervertebral discs, adjacent vertebrae also articulate with each other at synovial joints formed between the superior and inferior articular processes called zygapophysial joints (facet joints). These are plane joints that provide for only limited motions between the vertebrae. The orientation of the articular processes at these joints varies in different regions of the vertebral column and serves to determine the types of motions available in each...
3.5K
Eccentric Axial Loading in a Plane of Symmetry
661
Eccentric axial loading occurs when an axial load is applied away from the centroidal axis of a structural member. This scenario is common in engineering, where structural elements may not be directly aligned due to various design or functional requirements.
661
Axial and Appendicular Muscles
3.0K
Skeletal muscles, the key players in our body's movement, can be classified into two groups based on their location and function: axial muscles and appendicular muscles. These classifications reflect the primary roles the muscles play in the body's structure and movement.
Axial Muscles
Axial muscles, situated along the body's midline, are intricately connected to the axial skeleton, which includes the skull, spine, ribs, and sternum. These muscles facilitate facial expressions and...
Axial Muscles
Axial muscles, situated along the body's midline, are intricately connected to the axial skeleton, which includes the skull, spine, ribs, and sternum. These muscles facilitate facial expressions and...
3.0K
Functional Classification of Joints
8.5K
Functional Classification of Joints
The functional classification of joints is determined by the amount of mobility between the adjacent bones. Joints are functionally classified as a synarthrosis or immobile joint, an amphiarthrosis or slightly moveable joint, or as a diarthrosis, a freely moveable joint. Fibrous and cartilaginous joints can be functionally classified as either synarthroses or amphiarthroses, whereas all synovial joints are classified as diarthroses.
Synarthrosis
An...
The functional classification of joints is determined by the amount of mobility between the adjacent bones. Joints are functionally classified as a synarthrosis or immobile joint, an amphiarthrosis or slightly moveable joint, or as a diarthrosis, a freely moveable joint. Fibrous and cartilaginous joints can be functionally classified as either synarthroses or amphiarthroses, whereas all synovial joints are classified as diarthroses.
Synarthrosis
An...
8.5K
Genome-wide Association Studies-GWAS
16.3K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
GWAS does not require the identification of the target gene involved in...
16.3K


