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Updated: Feb 26, 2026

Functional Reconstitution and Channel Activity Measurements of Purified Wildtype and Mutant CFTR Protein
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Functional Reconstitution and Channel Activity Measurements of Purified Wildtype and Mutant CFTR Protein

Published on: March 9, 2015

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リン酸化とATP結合によるCFTRの適合変化

Zhe Zhang1, Fangyu Liu2, Jue Chen1

  • 1Laboratory of Membrane Biophysics and Biology, The Rockefeller University, New York, NY, USA; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.

Cell
|July 25, 2017
PubMed
まとめ

胞性線維症の膜伝導性調節器 (CFTR) の構造的な洞察は,リン酸化とATP結合がどのように主要な再配置を引き起こし,チャネルを開くかを明らかにする. 細胞外孔口は閉ざされていて,イオン流の局所的な制御を示唆しています.

キーワード:
ABCトランスポーターATPに結合するCFTR についてアニオンチャンネルクリオ・エムリン酸化された形

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