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Updated: Jan 22, 2026

Modeling Breast Cancer via an Intraductal Injection of Cre-expressing Adenovirus into the Mouse Mammary Gland
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不十分なDNA損傷修復は乳腺変異を促進し,BRCA1乳がんにつながる

Hua Wang1, Dongxi Xiang2, Ben Liu1

  • 1Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Departments of Genetics and Medicine, Harvard Medical School, Boston, MA 02115, USA.

Cell
|June 29, 2019
PubMed
まとめ

BRCA1機能の喪失は,DNAの損傷と細胞の変異を引き起こし,基礎的な乳がんにつながる. この研究は,修復されていないDNAの損傷が乳頭上皮細胞 (MEC) の悪性変異をどのように誘導するかを明らかにしています.

キーワード:
BRCA1 についてCtIPEMT についてHES1 についてICLの修理NUMB乳がん細胞の運命シスプラチンマウスモデル単細胞分析トランスディフェリエンテーション

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