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Updated: Dec 28, 2025

Using In Vitro Fluorescence Resonance Energy Transfer to Study the Dynamics Of Protein Complexes at a Millisecond Time Scale
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Using In Vitro Fluorescence Resonance Energy Transfer to Study the Dynamics Of Protein Complexes at a Millisecond Time Scale

Published on: March 14, 2019

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NEDD8は,多値クリン-RING-UBE2Dユビキチン結合組を核化する

Kheewoong Baek1, David T Krist1,2, J Rajan Prabu1

  • 1Department of Molecular Machines and Signaling, Max Planck Institute of Biochemistry, Martinsried, Germany.

Nature
|February 14, 2020
PubMed
まとめ

この研究では,NEDD8の改変が,タンパク質の普遍化のためにクリン- RING E3連鎖酶 (CRLs) を活性化する方法が明らかにされています. Cryo-EMは,NEDD8ブリッジのCRLコンポーネントとウビキチンを含むE2酵素を示し,基質のウビキティレーションを可能にします.

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