Jove
Visualize
お問い合わせ

関連する概念動画

Catalysis02:50

Catalysis

29.9K
The presence of a catalyst affects the rate of a chemical reaction. A catalyst is a substance that can increase the reaction rate without being consumed during the process. A basic comprehension of a catalysts’ role during chemical reactions can be understood from the concept of reaction mechanisms and energy diagrams.
29.9K
Reduction of Alkenes: Asymmetric Catalytic Hydrogenation02:17

Reduction of Alkenes: Asymmetric Catalytic Hydrogenation

3.8K
Catalytic hydrogenation of alkenes is a transition-metal catalyzed reduction of the double bond using molecular hydrogen to give alkanes. The mode of hydrogen addition follows syn stereochemistry.
The metal catalyst used can be either heterogeneous or homogeneous. When hydrogenation of an alkene generates a chiral center, a pair of enantiomeric products is expected to form. However, an enantiomeric excess of one of the products can be facilitated using an enantioselective reaction or an...
3.8K
Reduction of Alkynes to cis-Alkenes: Catalytic Hydrogenation02:24

Reduction of Alkynes to cis-Alkenes: Catalytic Hydrogenation

8.8K
Introduction
Like alkenes, alkynes can be reduced to alkanes in the presence of transition metal catalysts such as Pt, Pd, or Ni. The reaction involves two sequential syn additions of hydrogen via a cis-alkene intermediate.
8.8K
Nitriles to Amines: LiAlH4 Reduction00:55

Nitriles to Amines: LiAlH4 Reduction

4.4K
Nitriles are reduced to amines in the presence of strong reducing agents like lithium aluminum hydride through a typical nucleophilic acyl substitution. The reaction requires two equivalents of the reducing agent. The reducing agent acts as a source of hydride ions.
As shown below, the mechanism involves three steps. Firstly, the hydride ion acting as a nucleophile attacks the nitrile carbon to form an anion. In the second step, a second equivalent of the hydride ion attacks the anion to...
4.4K
Reduction of Alkenes: Catalytic Hydrogenation02:13

Reduction of Alkenes: Catalytic Hydrogenation

13.8K
Alkenes undergo reduction by the addition of molecular hydrogen to give alkanes. Because the process generally occurs in the presence of a transition-metal catalyst, the reaction is called catalytic hydrogenation.
Metals like palladium, platinum, and nickel are commonly used in their solid forms — fine powder on an inert surface. As these catalysts remain insoluble in the reaction mixture, they are referred to as heterogeneous catalysts.
The hydrogenation process takes place on the...
13.8K
Preparation of Amines: Reductive Amination of Aldehydes and Ketones01:38

Preparation of Amines: Reductive Amination of Aldehydes and Ketones

3.6K
Carbonyl compounds and primary amines undergo reductive amination first to produce imines, followed by secondary amines in the same reaction mixture, using selective reducing agents like sodium cyanoborohydride or sodium triacetoxyborohydride. Reductive amination produces different degrees of substitution of amines depending on the starting amine substrate.
3.6K

こちらも読む

関連記事

共著者、ジャーナル、引用グラフによってこの研究に関連する記事。

並び替え
Same author

Chemical Probes to Reveal the Assembly and Dynamics of Wall Teichoic Acids.

Journal of the American Chemical Society·2026
Same author

Enantioconvergent Chan-Evans-Lam C(sp<sup>3</sup>)-O Coupling: Cu-Catalyzed Asymmetric Benzyl- and Allylborane Oxidation.

Journal of the American Chemical Society·2026
Same author

Manipulating Terminal Iron-Hydroxide Nucleophilicity through Redox.

Journal of the American Chemical Society·2026
Same author

Hydride Transfer Reactivity of an Open-Shell [Fe<sub>3</sub>H]<sup>-</sup> Cluster.

Journal of the American Chemical Society·2025
Same author

Cu-catalyzed enantioconvergent deborylative alkynylation.

Chemical science·2025
Same author

Accessing Square Planar Cobalt Nitrenoid Redox Isomers across Three Oxidation States.

Journal of the American Chemical Society·2025
JoVE
x logofacebook logolinkedin logoyoutube logo
JoVEについて
概要リーダーシップブログJoVEヘルプセンター
著者向け
出版プロセス編集委員会範囲と方針査読よくある質問投稿
図書館員向け
推薦の声購読アクセスリソース図書館諮問委員会よくある質問
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experimentsアーカイブ
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教員リソースセンター教員サイト
利用規約
プライバシーポリシー
ポリシー

関連する実験動画

Updated: Dec 20, 2025

Palladium N-Heterocyclic Carbene Complexes: Synthesis from Benzimidazolium Salts and Catalytic Activity in Carbon-carbon Bond-forming Reactions
19:58

Palladium N-Heterocyclic Carbene Complexes: Synthesis from Benzimidazolium Salts and Catalytic Activity in Carbon-carbon Bond-forming Reactions

Published on: July 30, 2017

10.1K

ニッケル-ディピリン複合体を用いた効率的なC-Hアミネーション触媒

Yuyang Dong1, Ryan M Clarke1, Gerard J Porter1

  • 1Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, United States.

Journal of the American Chemical Society
|May 29, 2020
PubMed
まとめ
この要約は機械生成です。

新しいニッケル触媒は,室温でアリファティックアジドの効率的なC-Hアミネーションを可能にします. この反応は,速度を決定する水素原子抽象段階を経て,広範囲の基質範囲と機能群の許容性を有するN-ヘテロサイクルを形成します.

さらに関連する動画

Catalytic Reactions at Amine-Stabilized and Ligand-Free Platinum Nanoparticles Supported on Titania During Hydrogenation of Alkenes and Aldehydes
12:08

Catalytic Reactions at Amine-Stabilized and Ligand-Free Platinum Nanoparticles Supported on Titania During Hydrogenation of Alkenes and Aldehydes

Published on: June 24, 2022

3.9K
Mizoroki-Heck Cross-coupling Reactions Catalyzed by Dichloro{bis[1,1',1''-phosphinetriyltripiperidine]}palladium Under Mild Reaction Conditions
11:44

Mizoroki-Heck Cross-coupling Reactions Catalyzed by Dichloro{bis[1,1',1''-phosphinetriyltripiperidine]}palladium Under Mild Reaction Conditions

Published on: March 20, 2014

25.8K

関連する実験動画

Last Updated: Dec 20, 2025

Palladium N-Heterocyclic Carbene Complexes: Synthesis from Benzimidazolium Salts and Catalytic Activity in Carbon-carbon Bond-forming Reactions
19:58

Palladium N-Heterocyclic Carbene Complexes: Synthesis from Benzimidazolium Salts and Catalytic Activity in Carbon-carbon Bond-forming Reactions

Published on: July 30, 2017

10.1K
Catalytic Reactions at Amine-Stabilized and Ligand-Free Platinum Nanoparticles Supported on Titania During Hydrogenation of Alkenes and Aldehydes
12:08

Catalytic Reactions at Amine-Stabilized and Ligand-Free Platinum Nanoparticles Supported on Titania During Hydrogenation of Alkenes and Aldehydes

Published on: June 24, 2022

3.9K
Mizoroki-Heck Cross-coupling Reactions Catalyzed by Dichloro{bis[1,1',1''-phosphinetriyltripiperidine]}palladium Under Mild Reaction Conditions
11:44

Mizoroki-Heck Cross-coupling Reactions Catalyzed by Dichloro{bis[1,1',1''-phosphinetriyltripiperidine]}palladium Under Mild Reaction Conditions

Published on: March 20, 2014

25.8K

科学分野:

  • 有機金属化学
  • カタリシス
  • 有機合成

背景:

  • 内分子C-Hアミネーションは,N-ヘテロサイクルを合成するための重要な変換である.
  • 温和で効率的なC−H機能化のための触媒システムの開発は,依然として重要な課題です.
  • ニッケル触媒は,惰性C−H結合を活性化するための有望な手段である.

研究 の 目的:

  • アリファティックアジドを用いた分子内C-Hアミネーションのための新しいニッケル触媒を開発する.
  • 触媒システムの範囲,化学選択性,機能群耐性を調査する.
  • 速度を決定するステップと触媒の静止状態を含む反応メカニズムを明らかにする.

主な方法:

  • ディピリンサポートニッケル触媒の合成と特徴付け
  • 様々なC-H結合型と機能群を含むC-Hアミネーションのための基板の範囲の探索.
  • 核磁共振 (NMR) スペクトロスコーピー,運動同位体効果 (KIE) 測定,アイリング分析を用いたメカニズム研究.

主要な成果:

  • (AdFL) Ni(py) 触媒は,軽度な条件 (室温,0. 1−2モル%の負荷) の下で,分子内C−Hアミネーションを効率的に促進する.
  • この反応は,より弱いC-H結合に対して高い化学選択性を持つベンジル系,三次性,二次性,および一次性C-H結合を成功裏にアミナ化する幅広い基板範囲を示している.
  • 機械的調査は,H原子のトンネリングを含む速度を決定する水素原子抽象ステップを明らかにし,触媒の静止状態はニッケルイミニル基として識別される.

結論:

  • N-ヘテロサイクルの合成を可能にする,分子内C-Hアミネーションのための非常に効果的なニッケル触媒が開発されました.
  • 反応は軽い条件下で進行し,優れた機能群耐性および化学選択性を示します.
  • 機械学的な研究は,水素原子抽出とトンネリングの重要性を強調し,触媒サイクルに対する重要な洞察を提供します.