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関連する概念動画

Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Histone Modification02:32

Histone Modification

The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
Acetylation
The enzyme histone acetyltransferase adds acetyl group to the histones. Another enzyme, histone deacetylase,...
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Genomic Imprinting and Inheritance02:30

Genomic Imprinting and Inheritance

Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
Epigenetic Regulation01:37

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
Histone Modification02:32

Histone Modification

The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
Acetylation
The enzyme histone acetyltransferase adds acetyl group to the histones. Another enzyme, histone deacetylase,...

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関連する実験動画

Updated: Jul 1, 2026

Correlating Gene-specific DNA Methylation Changes with Expression and Transcriptional Activity of Astrocytic KCNJ10 (Kir4.1)
11:19

Correlating Gene-specific DNA Methylation Changes with Expression and Transcriptional Activity of Astrocytic KCNJ10 (Kir4.1)

Published on: September 26, 2015

DNAメチル化と遺伝子活性について

H Cedar1

  • 1Department of Cellular Biochemistry, Hebrew University, Jerusalem, Israel.

Cell
|April 8, 1988
PubMed
まとめ

DNAメチル化は,染色体の構造を変えることで,組織特有の遺伝子を抑制し,それらをアクセス不能にします. 遺伝子の活性化には脱メチル化が含まれ,構成的発現を可能にします.

科学分野:

  • 分子生物学は分子生物学である.
  • エピジェネティクス エピジェネティクス
  • 遺伝子規制 遺伝子規制

背景:

  • DNAメチル化は,重要な表遺伝的メカニズムである.
  • 組織特異的な遺伝子発現は,細胞の分化に不可欠です.
  • 遺伝子抑制メカニズムを理解することは,発達生物学にとって不可欠です.

研究 の 目的:

  • 組織特異的な遺伝子発現を in vivo で調節するDNAメチル化の役割を明らかにする.
  • DNAメチル化がトランスクリプション抑制にどのように貢献するかについてのモデルを提案する.
  • DNA脱メチル化を含む遺伝子活性化のプロセスを説明する.

主な方法:

  • この研究は,実験結果に基づいています (詳細は抽象文に記載されていません).
  • このモデルは,染色体構造と遺伝子アクセシビリティの概念を統合しています.
  • 組織特異性および家政遺伝子の比較分析が暗示されています.

主要な成果:

  • ほとんどの組織特異遺伝子はメチル化され,転写不活性につながります.
  • メチル化により,遺伝子のアクセスをブロックするクロマチンの状態が生まれます.

さらに関連する動画

Immunostaining for DNA Modifications: Computational Analysis of Confocal Images
09:42

Immunostaining for DNA Modifications: Computational Analysis of Confocal Images

Published on: September 7, 2017

Continuous Fluorescence-Based Endonuclease-Coupled DNA Methylation Assay to Screen for DNA Methyltransferase Inhibitors
06:07

Continuous Fluorescence-Based Endonuclease-Coupled DNA Methylation Assay to Screen for DNA Methyltransferase Inhibitors

Published on: August 5, 2022

関連する実験動画

Last Updated: Jul 1, 2026

Correlating Gene-specific DNA Methylation Changes with Expression and Transcriptional Activity of Astrocytic KCNJ10 (Kir4.1)
11:19

Correlating Gene-specific DNA Methylation Changes with Expression and Transcriptional Activity of Astrocytic KCNJ10 (Kir4.1)

Published on: September 26, 2015

Immunostaining for DNA Modifications: Computational Analysis of Confocal Images
09:42

Immunostaining for DNA Modifications: Computational Analysis of Confocal Images

Published on: September 7, 2017

Continuous Fluorescence-Based Endonuclease-Coupled DNA Methylation Assay to Screen for DNA Methyltransferase Inhibitors
06:07

Continuous Fluorescence-Based Endonuclease-Coupled DNA Methylation Assay to Screen for DNA Methyltransferase Inhibitors

Published on: August 5, 2022

  • ハウスクイピング遺伝子は,一般的に,このメチル化誘発抑制によって影響を受けません.
  • 遺伝子の活性化は,メチル化遺伝子の認識から始まり,その後,脱メチル化が続きます.
  • 脱メチル化された遺伝子は,安定した,活性クロマチンの構造を採用します.

    • 結論:

    • DNAメチル化は,規制因子から独立して,転写抑制のための一般的なメカニズムを提供します.
    • このメカニズムは,異なる遺伝子発現を可能にし,細胞タイプ特異性を可能にします.
    • 脱メチル化は,組織特異遺伝子の安定した活性化と維持に不可欠である.