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Isolation of Murine Lymph Node Stromal Cells
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リンパ節における単細胞由来S1Pは,免疫反応を調節する

Audrey Baeyens1, Sabrina Bracero1,2, Venkata S Chaluvadi1,3

  • 1Skirball Institute of Biomolecular Medicine, New York University Langone Medical Center, New York, NY, USA.

Nature
|March 4, 2021
PubMed
まとめ

Sphingosine 1-phosphate (S1P) のレベルは,炎症性モノサイトによって駆動される免疫反応の間にリンパ節で上昇します. この増加はT細胞の居住期間を延長し,自己免疫疾患の重症性を悪化させる.

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