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関連する概念動画

Proteomics01:33

Proteomics

8.6K
A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...
8.6K
Protein Networks02:26

Protein Networks

4.2K
An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
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関連する実験動画

Updated: Oct 21, 2025

Deep Proteome Profiling by Isobaric Labeling, Extensive Liquid Chromatography, Mass Spectrometry, and Software-assisted Quantification
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Deep Proteome Profiling by Isobaric Labeling, Extensive Liquid Chromatography, Mass Spectrometry, and Software-assisted Quantification

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スナップショット:臨床プロテオミクス

Yi Zhu1, Ruedi Aebersold2, Matthias Mann3

  • 1Westlake Laboratory of Life Sciences and Biomedicine, Westlake University, Hangzhou, China.

Cell
|September 3, 2021
PubMed
まとめ
この要約は機械生成です。

臨床試料の定量プロテオミク分析は,健康と病気に関する重要な洞察を提供します. この概要は,タンパク質の組成を分析するための一般的なおよび新興の質量スペクトロメトリ (MS) ワークフローを網羅しています.

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Comprehensive Workflow of Mass Spectrometry-based Shotgun Proteomics of Tissue Samples
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A Clinical Metaproteomics Workflow Implemented within Galaxy Bioinformatics Platform to Analyze Host-Microbiome Interactions Underlying Human Disease
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A Clinical Metaproteomics Workflow Implemented within Galaxy Bioinformatics Platform to Analyze Host-Microbiome Interactions Underlying Human Disease

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Last Updated: Oct 21, 2025

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Published on: January 10, 2025

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科学分野:

  • 生物化学
  • 分析化学
  • 臨床プロテオミクス

背景:

  • 臨床試料の定量プロテオミク分析は,生理学的および病理学的状態を理解するために不可欠です.
  • 多くの方法論が存在し,現在のアプローチの要約が必要である.

研究 の 目的:

  • 定量プロテオミク分析のための一般的なおよび新興の質量スペクトロメトリー (MS) ベースのワークフローの概要を提供します.
  • 臨床環境におけるタンパク質解析の重要性を強調する.

主な方法:

  • マススペクトロメトリー (MS) ベースのワークフローが主な焦点です.
  • 議論は既定のMS技術と新しいMS技術の両方を含む.

主要な成果:

  • 概要は,MSベースのワークフローの要約を示しています.
  • 概要の性質とスペースの制限のため,具体的な結果は詳細に記載されていません.

結論:

  • MSを用いた定量プロテオミック分析は,臨床研究にとって貴重なツールです.
  • この分野は,新興のMSの方法論とともに進化し続けています.