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Barrett Esophagus-II: Clinical Manifestations and Management01:21

Barrett Esophagus-II: Clinical Manifestations and Management

347
Individuals with Barrett's esophagus are often asymptomatic, but they may experience symptoms commonly associated with GERD, such as heartburn and acid regurgitation. Additional symptoms can include difficulty swallowing, chest pain, unintentional weight loss, blood in the stool (which may appear black, tarry, or bloody), and episodes of vomiting.
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
347
Gastroesophageal Reflux Disease II: Clinical Features and Management01:29

Gastroesophageal Reflux Disease II: Clinical Features and Management

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Gastroesophageal reflux disease, or GERD, is a persistent medical condition that affects many individuals worldwide. Its clinical manifestations can vary greatly, making diagnosis and management challenging for healthcare professionals. The following is a comprehensive overview of the clinical manifestations, assessment, and management strategies for GERD.
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
256
Esophageal Strictures-I: Introduction01:30

Esophageal Strictures-I: Introduction

317
Esophageal strictures involve abnormal narrowing or tightening of the esophagus. They vary in length and severity, ranging from mild constriction to complete obstruction, and are classified as benign (noncancerous) or malignant (cancerous).
Etiology
The primary cause of esophageal strictures is long-standing gastroesophageal reflux disease (GERD), accounting for about 70 to 80% of adult cases. Chronic acid reflux can lead to injury and scarring of the esophageal lining, culminating in...
317
Barrett Esophagus-I: Introduction01:21

Barrett Esophagus-I: Introduction

259
Barrett's esophagus is a medical condition where the esophageal mucosa is significantly damaged by stomach acid or other digestive fluids, often due to long-term exposure associated with gastroesophageal reflux disease (GERD). In GERD, a weakened or abnormally relaxed lower esophageal sphincter allows stomach acid to flow persistently into the esophagus.
This constant acid exposure transforms the esophagus's pink mucosal lining (stratified squamous epithelium) into a type of lining more...
259
Esophageal Strictures-II: Clinical Features and Management01:26

Esophageal Strictures-II: Clinical Features and Management

189
Patients with esophageal strictures often experience a range of symptoms. Initially, they may have difficulty swallowing solid foods, which can progress to include liquids. Additional symptoms may involve chest pain or discomfort, regurgitating food and fluids, heartburn, unintentional weight loss, coughing or choking during meals, and hoarseness.
Healthcare providers should gather a comprehensive medical history and conduct a physical examination for diagnosis. If esophageal stricture is...
189
Gastroesophageal Reflux Disease I: Meaning and Pathophysiology01:29

Gastroesophageal Reflux Disease I: Meaning and Pathophysiology

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Gastroesophageal Reflux Disease (GERD) involves the recurrent backflow of the stomach or duodenal contents into the esophagus, leading to troublesome symptoms and potential esophageal mucosal damage. Although GERD is often referred to as a disease, it is more accurately described as a syndrome, as it encompasses a range of symptoms and complications rather than a singular pathological entity, impacting a large number of individuals as the most prevalent upper gastrointestinal problem. Roughly...
612

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エオシノフィルの食道炎: レビュー

Amanda Muir1, Gary W Falk2

  • 1Division of Gastroenterology, Hepatology, and Nutrition, Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia.

JAMA
|October 5, 2021
PubMed
まとめ
この要約は機械生成です。

エオシノフィル性食道炎 (EoE) は,34 / 100,000人以上に影響を与える慢性食道疾患です. 治療には PPI,ステロイド,食事の変更が含まれています.

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科学分野:

  • 胃腸内科
  • 免疫学
  • 病理学について

背景:

  • エオシノフィル性食道炎 (EoE) は,免疫媒介による慢性食道疾患である.
  • 子供と成人の両方に影響し 消化不全と食道収縮を引き起こします
  • 世界では約10万人当たり34.4人.

研究 の 目的:

  • エオシノフィル性食道炎 (EoE) の現在の理解をレビューする.
  • 診断基準とEoEの治療方法をまとめます
  • 治療の効果を評価する

主な方法:

  • 観察研究の体系的レビュー
  • ランダム化制御試験の体系的レビュー
  • プロトンポンプ阻害剤と局所用コルチコステロイドに対する組織学的反応率の分析.

主要な成果:

  • プロトンポンプ阻害剤 (PPI) 療法では,プラセボの13. 3%に対して41. 7%の組織学的応答率が示されました.
  • 局所用コルチコステロイドは,プラセボの13. 3%と比較して,患者の64. 9%で組織学的寛解を達成しました.
  • 消化管の拡張は,症状の狭窄を有する患者に示されています.

結論:

  • EoEは重要な食道疾患であり,標的治療が必要である.
  • プロトンポンプ阻害剤と局所用コルチコステロイドは効果的な治療法です.
  • 食事の変更と内視拡張も重要な管理戦略です.