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Updated: May 2, 2026

Rapid and Robust Analysis of Cellular and Molecular Polarization Induced by Chemokine Signaling
10:03

Rapid and Robust Analysis of Cellular and Molecular Polarization Induced by Chemokine Signaling

Published on: December 12, 2014

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ヒトT細胞におけるタンパク質キナーゼC調節体のトポロジック異質性は,細胞内ダイナミック核極化NMRスペクトロスコーピーで解明された

Sarah A Overall1, Sina J Hartmann1, Quang H Luu-Nguyen2

  • 1Institute of Molecular Physical Science, ETH Zurich, 8093 Zurich, Switzerland.

Journal of the American Chemical Society
|September 25, 2024
PubMed
まとめ

この研究では,13C-21,22-ホルボルミリスタートアセテート (PMA) のようなホルボルエステルアナログがT細胞膜とどのように相互作用するかを明らかにするために,細胞内DNP-NMRを使用しています. 発見は,PMAが膜に定着することを示し,生物学的活動に影響を与える可能性のある浅い結合モードを示唆しています.

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