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Bacterial Meningitis01:24

Bacterial Meningitis

Bacterial meningitis is a severe infectious disease involving inflammation of the meninges, the protective membranes surrounding the brain and spinal cord. It occurs when pathogenic bacteria cross the blood–brain barrier and enter the cerebrospinal fluid. Common causative organisms include Neisseria meningitidis, Streptococcus pneumoniae, Haemophilus influenzae type b, Listeria monocytogenes, and Escherichia coli K1. The exact route of entry varies by pathogen and host condition.Routes of Entry...
Viral Meningitis01:18

Viral Meningitis

Viral meningitis is the most common form of meningitis and is often referred to as aseptic meningitis to indicate the absence of bacterial involvement. It is generally milder than bacterial meningitis, with symptoms including fever, headache, stiff neck, drowsiness, nausea, photophobia, and vomiting. Rarely, more severe manifestations or death may occur. Common causative agents include enteroviruses, particularly coxsackie A and B viruses and echoviruses, all members of the Enterovirus genus...
Arboviral Encephalitis01:25

Arboviral Encephalitis

Arboviral encephalitis refers to brain inflammation caused by arthropod-borne viruses, particularly those transmitted through mosquito vectors. Among these, West Nile virus (WNV), a member of the Flaviviridae family, is a significant public health concern. WNV is an enveloped, positive-sense, single-stranded RNA virus. Human infection typically begins when an infected mosquito introduces the virus into the dermis during feeding. The primary transmission cycle involves birds as amplifying hosts...
Cytomegalovirus Disease01:27

Cytomegalovirus Disease

Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...
Cryptococcal Meningitis01:27

Cryptococcal Meningitis

Cryptococcal meningitis is a life-threatening opportunistic infection predominantly associated with HIV/AIDS, accounting for over 100,000 deaths annually worldwide. However, it also affects individuals with other forms of immunosuppression, including those undergoing immunosuppressive therapy, organ transplant recipients, patients with innate immunodeficiencies, and individuals with hematological disorders. The infection is caused mainly by Cryptococcus neoformans and Cryptococcus gattii,...
Antiviral Nucleoside Inhibitors01:22

Antiviral Nucleoside Inhibitors

Antiviral Nucleoside InhibitorsAntiviral nucleoside inhibitors are structural analogs of natural nucleosides that interfere with viral DNA or RNA synthesis. These compounds selectively target viral polymerases due to their resemblance to host nucleosides, thereby disrupting viral genome replication.Mechanism of Acyclovir ActionAcyclovir is a guanosine analog with a three-carbon acyclic side chain. It selectively targets herpes simplex virus type 1 (HSV-1), herpes simplex virus type 2 (HSV-2),...

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Using a Pan-Viral Microarray Assay Virochip to Screen Clinical Samples for Viral Pathogens
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単複合ウイルスPCRの使用とアシクロビールの利用は,第三次ケアがんセンターにおけるBioFire Meningitis/ Encephalitisパネルの実施後に減少した.

Tracy McMillen1, Eleanor Powell1,2, Krupa Jani1

  • 1Clinical Microbiology Service, Department of Pathology and Laboratory Medicine, USA.

Journal of clinical virology plus
|September 2, 2025
PubMed
まとめ

BioFireの脳膜炎/脳炎 (M/E) パネルは,がん患者のウイルスPCR検査とアシクロビールの使用量を減少させた. この診断ツールは,この脆弱な集団における脳膜炎と脳炎の治療効率を向上させました.

キーワード:
アシクロビール癌について脳の炎症髄膜炎マルチプレックスPCR急速診断検査

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科学分野:

  • 感染症 診断
  • 腫瘍学
  • 臨床微生物学

背景:

  • 髄膜炎と脳炎は 非常事態です
  • バイオファイアの脳膜炎/脳炎 (M/E) パネルは,脳脊髄液 (CSF) で14の病原体を検出します.
  • M/ Eパネルのがん患者への影響に関するデータは限られている.

研究 の 目的:

  • 癌患者の抗ウイルスおよびウイルス検査の利用に対するM/Eパネルの影響を評価する.
  • 導入後のアシクロビールとシングルプレックスPCR試験の変化を評価する.
  • 治療期間と患者数に対するM/Eパネルの効果を分析する.

主な方法:

  • 介入前と介入後の研究デザインが採用された.
  • 研究室と臨床情報システムからデータを収集した.
  • 476人のがん患者 (207人が介入前,269人が介入後) を分析した.

主要な成果:

  • シングルプレックスウイルスPCR検査は,M/ Eパネル導入後の64. 9%減少した.
  • アシクロビールの治療は介入後のグループで29. 1%減少した.
  • アシクロビールの治療期間が著しく短縮された (p < 0. 0274).

結論:

  • M/Eパネルの実施は,がん患者のシングルプレックスPCR検査を減少させた.
  • このパネルは,アシクロビールの利用と治療期間を短縮することに寄与した.
  • BioFire M/Eパネルは,がん患者の脳膜炎/脳炎の診断と治療法を最適化しています.