RNF4の逐次的ネイティブ化学ライゲーションによる全化学合成:C末端からN末端戦略 vs N末端からC末端戦略
Rajesh Pallava1, Saed Bisher1, Ashraf Brik1
1Schulich Faculty of Chemistry, Technion - Israel Institute of Technology, 3200008 Haifa, Israel.
The Journal of organic chemistry
|February 4, 2026
まとめ
研究者らは、がんにおける役割の研究を可能にする、主要なE3ユビキチンリガーゼであるRNF4を化学合成した。この複雑なタンパク質合成には、N末端からC末端ライゲーション法がより効率的であることが証明された。
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