-
rabindra.tharu.np@gmail.com
·
REST and RCOR genes display distinct expression profiles in neurons and astrocytes using 2D and 3D human pluripotent stem cell models
Repressor element-1 silencing transcription factor (REST) is a transcriptional repressor involved in neurodevelopment and neuroprotection. REST forms a complex with the REST corepressors, CoREST1, CoREST2, or CoREST3 (encoded by , , and , respectively). Emerging evidence suggests that the CoREST family can target unique genes independently of REST, in various neural and glial cell types…
-
rabindra.tharu.np@gmail.com
·
Macrotermes subhylanus flour inclusion in biscuits: Effects on nutritional, sensorial and microbial characteristics
As the world’s population expands, edible insects have been proposed as a food source that might address issues related to nutrition, health, the environment, and the economy. This study aimed to create a novel biscuit by adding () flour to wheat flour in various concentrations (5,10, 15 and 20 %). The moisture content of the insect…
-
rabindra.tharu.np@gmail.com
·
Sustained feeding of a diet high in fat resulted in a decline in the liver’s insulin-degrading enzyme levels in association with the induction of oxidative and endoplasmic reticulum stress in adult male rats: Evaluation of 4-phenylbutyric acid
The current study explored the impact of high fat diet (HFD) on hepatic oxidative and endoplasmic reticulum (ER) stress and its insulin degrading enzyme (IDE) content with the injection of 4-phenyl butyric acid (4-PBA) in adult male rats. Following the weaning period, male offspring were distributed among six distinct groups. The corresponding diet was used…
-
rabindra.tharu.np@gmail.com
·
Application of Monte Carlo simulation to optimise the dosage regimen of meropenem in patients with augmented renal clearance for Pseudomonas aeruginosa infection
OBJECTIVE To optimise the dosing regimen of meropenem for treating (PA) infections in critically ill patients with augmented renal clearance (ARC) using pharmacokinetic/pharmacodynamic (PK/PD) principles and Monte Carlo simulation (MCS). METHODS This research involves an MCS based on PK data from patients with ARC and a minimum inhibitory concentration (MIC) distribution of PA. This study…
-
rabindra.tharu.np@gmail.com
·
Transfer of heavy metals from soil to vegetables: A comparative assessment of different irrigation water sources
This study aimed to assess the transfer factor (TF) of heavy metals (HMs) from soil to commonly consumed vegetables irrigated with different water sources. The field study covered 36 m of agricultural land in Kermanshah province, Iran, divided into nine equal-sized plots. Coriander, basil, and radish were the three types of vegetables cultivated and subjected to…
-
rabindra.tharu.np@gmail.com
·
A rapid protocol for synthesis of chitosan nanoparticles with ideal physicochemical features
In this research, an innovative protocol is introduced to address crucial deficiencies in the formulation of chitosan nanoparticles (Cs NPs). While NPs show potential in drug delivery systems (DDSs), their application in the clinic is hindered by various drawbacks, such as toxicity, high material costs, and time-consuming and challenging preparation procedures. Within polymer-based NPs, Cs…
-
rabindra.tharu.np@gmail.com
·
Effective multidimensional treatment identification of different chemical fertilizers: Response of insect dynamics and rice production
Effective management of fertilizers is essential in influencing the prevalence of insects in rice ( L.) fields. Over two years (2019-20 and 2020-21), an experiment conducted at Bangladesh Rice Research Institute (BRRI), Habiganj, during the boro season aimed to identify the most effective multidimensional treatment (EMT) by testing various combinations of chemical fertilizers and its…
