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rabindra.tharu.np@gmail.com
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Predictive modeling for ubiquitin proteins through advanced machine learning technique
Ubiquitination is an essential post-translational modification mechanism involving the ubiquitin protein’s bonding to a substrate protein. It is crucial in a variety of physiological activities including cell survival and differentiation, and innate and adaptive immunity. Any alteration in the ubiquitin system leads to the development of various human diseases. Numerous researches show the highly reversibility…
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rabindra.tharu.np@gmail.com
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Development of 3D skin equivalents for application in photodynamic biostimulation therapy assays using curcumin nanocapsules
For decades, animal models have been the standard approach in drug research and development, as they are required by regulations in the transition from preclinical to clinical trials. However, there is growing ethical and scientific concern regarding these trials, as 80 % of the therapeutic potential observed in pre-clinical studies are often unable to be replicated,…
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rabindra.tharu.np@gmail.com
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Mucin phenotype and microvessels in early gastic cancer: Magnifying endoscopy with narrow band imaging
BACKGROUNDS In order to detect early gastric cancer (EGC), this research sought to assess the diagnostic utility of magnifying endoscopy (ME) as well as the significance of mucin phenotype and microvessel features. METHODS 402 individuals with an EGC diagnosis underwent endoscopic submucosal dissection (ESD) at the Department of ME between 2012 and 2020. After adjusting…
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rabindra.tharu.np@gmail.com
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Bibliometric analysis of global research on air pollution and cardiovascular diseases: 2012-2022
BACKGROUND The relationship between air pollution and cardiovascular diseases (CVDs) has garnered significant interest among researchers globally. This study employed bibliometric analysis to provide an overview of current research on the association between air pollution and CVDs, offering a comprehensive analysis of global research trends in this area. METHODS An exhaustive scrutiny of literature pertaining…
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rabindra.tharu.np@gmail.com
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Generative artificial intelligence in healthcare from the perspective of digital media: Applications, opportunities and challenges
INTRODUCTION The emergence and application of generative artificial intelligence/large language models (hereafter GenAI LLMs) have the potential for significant impact on the healthcare industry. However, there is currently a lack of systematic research on GenAI LLMs in healthcare based on reliable data. This article aims to conduct an exploratory study of the application of GenAI…
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rabindra.tharu.np@gmail.com
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Antioxidant activity, total polyphenol, anthocyanin and benzyl-glucosinolate contents in different phenotypes and portion of Japanese Maca (Lepidium meyenii)
Maca (), mainly grown in Peru, is a traditional herbal medicine that is mostly used to improve sperm motility and serum hormone levels. Maca phenotypes are represented by purple, black, yellow, white, and mixed colors. Recently, a method for Maca cultivation has been established in Japan. Therefore, we determined the effects of different phenotypes and…
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rabindra.tharu.np@gmail.com
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Effects of different plasma treatments on bonding properties of zirconia
This in vitro study was to evaluate the effect of different non-thermal atmospheric pressure plasma (NTP) on shear bond strength (SBS) between yttria-stabilized tetragonal zirconia polycrystal (Y-TZP) and self-adhesive resin cement. In this study, The Y-TZP specimens were divided into 4 groups according to the surface treatment methods as follows: Control (no surface treatment), Sb…
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rabindra.tharu.np@gmail.com
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Global trends of single cell sequence associated in cancer from 2011 to 2024: A bibliometric analysis
OBJECTIVE Exploring the different molecular and clinicopathological features of nodal cancer based on single cell sequencing can reveal the intertumoral heterogeneity in cancer, and provide new ideas for early diagnosis, treatment and prognosis analysis of cancer. METHODS The hotspots, the features of worldwide scientific output, and the frontiers concerning single cell sequence related to cancer…
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rabindra.tharu.np@gmail.com
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Unlocking the therapeutic potential of Huoxiang Zhengqi San in cold and high humidity-induced diarrhea: Insights into intestinal microbiota modulation and digestive enzyme activity
Huoxiang Zhengqi San (HXZQS), a traditional Chinese herbal formula, enjoys widespread use in Chinese medicine to treat diarrhea with cold-dampness trapped spleen syndrome (CDSS), which is induced by exposure to cold and high humidity stress. This study aimed to explore its therapeutic mechanisms in mice, particularly focusing on the intestinal microbiota. Forty male SPF-grade KM…
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rabindra.tharu.np@gmail.com
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Effects of cardiac rehabilitation on cognitive function in patients with acute coronary syndrome: A systematic review
BACKGROUND Construction of an intervention method for the cognitive dysfunction of patients with acute coronary syndrome (ACS) is needed. Exercise-based comprehensive cardiac rehabilitation is a potentially effective approach that can improve cognitive function in ACS patients. This study aimed to investigate the effect of cardiac rehabilitation on cognitive function in ACS patients through a systematic…
