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Global trends of single cell sequence associated in cancer from 2011 to 2024: A bibliometric analysis

Affiliations
  • 1Department of General Surgery, The First Affiliated Hospital of Hebei North University, 075000, China.
  • 2Institute of Cancer, The First Affiliated Hospital of Hebei North University, 075000, China.
  • 3College of Medical Technology, Chengdu University of Traditional Chinese Medicine, Chengdu, 610000, China.
  • 4School of Basic Medicine, Fourth Military Medical University, Xi’an, 710032, China.
  • 5Department of Gynaecology, Xinchang Country People’s Hospital/Xinchang County Maternal and Child Health Hospital, 117 Gushan Middle Road, Xinchang, 312500, Zhejiang Province, China.

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July 8, 2024

Abstract

OBJECTIVE

Exploring the different molecular and clinicopathological features of nodal cancer based on single cell sequencing can reveal the intertumoral heterogeneity in cancer, and provide new ideas for early diagnosis, treatment and prognosis analysis of cancer.

METHODS

The hotspots, the features of worldwide scientific output, and the frontiers concerning single cell sequence related to cancer from 2011 to 2024 were determined using our bibliometric analysis. Web of Science Core Collection (WOSCC) database was searched for publications on single cell sequence associated with cancer that were published between 2011 and 2024. According to the journals, keywords, number of records, affiliations, citations, and countries, we conducted a bibliometric analysis. With the use of the data gathered from the WOSCC, geographic distribution was visualized, keyword, affiliation, and author cluster analyses were conducted, and co-cited references were reviewed and a descriptive analysis was also performed.

RESULTS

From the analysis, it was concluded that 6189 articles that were published between 2011 and 2024 in total were identified. Frontiers in immunology is the leading journal with the most publications in field of the research. The five clusters that were identified for hotspots included immunotherapy, single-cell RNA sequencing, hepatocellular carcinoma, proliferation, gene expression appeared the most frequently. Journals, nations, organizations, scholars with most contribution and most referenced publications globally were extracted. Studies have mostly concentrated on the spatial transcriptomics, pan-cancer analysis, hepatocellular carcinoma et al.

CONCLUSION

Single-cell sequencing plays a significant role in tumor diagnosis, treatment and prognosis.

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