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rabindra.tharu.np@gmail.com
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Comparative fitness trade-offs associated with azole resistance in Candida auris clinical isolates
Multidrug-resistant yeast is a serious threat to public health with documented survival in various hospital niches. The dynamics of this survival benefit and its trade off with drug resistance are still unknown for this pathogen. In this study we investigate the oxidative stress response (OSR) in fluconazole-resistant and compare its relative fitness with fluconazole-susceptible strains.…
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rabindra.tharu.np@gmail.com
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Soil erosion assessment and identification of erosion hotspot areas in the upper Tekeze Basin, Northern Ethiopia
Soil erosion is a major environmental problem in Ethiopia, reducing topsoil and agricultural land productivity. Soil loss estimation is a critical component of sustainable land management practices because it provides important information about soil erosion hotspot areas and prioritizes areas that require immediate management interventions. This study integrates the Revised Universal Soil Loss Equation (RUSLE)…
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rabindra.tharu.np@gmail.com
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Improving protein extraction and peptide production from Chlorella vulgaris using combined mechanical/physical and enzymatic pre-treatments
is a microalga rich in proteins with potential applications in food and feed industries. However, the presence of a cellulose-containing cell wall, which is a major barrier to protein extraction, together with fibroproteinaceous complexes, limits the bioaccessibility of nutritional and bioactive proteins and peptides from biomass. Therefore, this study aimed to evaluate the effect of…
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rabindra.tharu.np@gmail.com
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Baicalin reduced injury of and autophagy-related gene expression in RAW264.7 cells infected with H6N6 avian influenza virus
In the present study, we investigated whether baicalin could reduce the damage caused to RAW264.7 cells following infection with H6N6 avian influenza virus. In addition, we studied the expression of autophagy-related genes. The morphological changes in cells were observed by hematoxylin and eosin (H&E) staining, and the inflammatory factors in the cell supernatant were detected by…
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rabindra.tharu.np@gmail.com
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A flexible and dissolving traditional Chinese medicine microneedle patch for sleep-aid intervention
About a quarter of the world’s population suffers from insomnia, and the number of the insomniacs is gradually increasing. However, the current drug therapy and non-drug therapy sleep-aid methods have certain limitations. In general, the sleep-aid effect of drug therapy is better than that of Non-drug therapy, but western medicine may lead to some side…
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rabindra.tharu.np@gmail.com
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Associations between type 1 diabetes and autoimmune skin diseases: Mendelian randomization analysis
BACKGROUND Type 1 diabetes mellitus (T1DM) may be associated with various autoimmune diseases, but the causal relationship between T1DM and autoimmune skin diseases is not yet clear. METHODS The summary statistical data on T1DM and nine autoimmune skin diseases in European populations were extracted for mendelian randomization (MR) analysis. Subsequently, the analysis was replicated in…
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rabindra.tharu.np@gmail.com
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Association between the recommended volume of leisure-time physical activity and erectile dysfunction: A cross-sectional analysis of the national health and nutrition examination survey, 2001-2004
OBJECTIVE Physical activity-related interventions alleviate the severity of erectile dysfunction (ED), but it is unknown whether the recommended volume of physical activity (PA) or a higher level of physical activity reduces the likelihood of ED in adult males. We aimed to evaluate the association between the recommended volume of PA and ED among US male…
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rabindra.tharu.np@gmail.com
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A QSPR analysis and curvilinear regression models for various degree-based topological indices: Quinolone antibiotics
Topological indices play an essential role in defining a chemical compound numerically and are widely used in QSPR/QSAR analysis. Using this analysis, physicochemical properties of the compounds and the topological indices are studied. Quinolones are synthetic antibiotics employed for treating the diseases caused by bacteria. Across the years, Quinolones have shifted its position from minor…
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rabindra.tharu.np@gmail.com
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A non-invasive AI-based system for precise grading of anosmia in COVID-19 using neuroimaging
COVID-19 (Coronavirus), an acute respiratory disorder, is caused by SARS-CoV-2 (coronavirus severe acute respiratory syndrome). The high prevalence of COVID-19 infection has drawn attention to a frequent illness symptom: olfactory and gustatory dysfunction. The primary purpose of this manuscript is to create a Computer-Assisted Diagnostic (CAD) system to determine whether a COVID-19 patient has normal,…
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rabindra.tharu.np@gmail.com
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Comparative study on chemical constituents of different medicinal parts of Lonicera japonica Thunb. Based on LC-MS combined with multivariate statistical analysis
Lonicerae japonicae flos (LJF), Lonicerae japonicae caulis (LJC), Lonicerae folium (LF) and Lonicerae fructus (LFR) are derived from Thunb., which are formed due to different medicinal parts. The efficacy of the 4 medicinal materials has similarities and differences. However, little attention has been paid to illustrate the differences in efficacy from the perspective of phytochemistry.…
