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rabindra.tharu.np@gmail.com
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TMAO is involved in kidney-yang deficiency syndrome diarrhea by mediating the “gut-kidney axis”
BACKGROUND Trimethylamine-N-oxide (TMAO) is a harmful metabolite dependent on the intestinal microbiota and excreted through the kidneys. According to numerous investigations, rich circulation concentrations of TMAO have been linked to kidney and gastrointestinal disorders. Through the “gut-kidney axis” mediated by TMAO, this research attempted to clarify the microbiological causes of kidney-yang deficiency syndrome diarrhea. METHODS…
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rabindra.tharu.np@gmail.com
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Health-related outcomes of structured home-based rehabilitation programs among older adults: A systematic literature review
The aging population reveals the need to develop self-care interventions that promote autonomy and well-being. The current systematic review aimed to assess the association between the implementation of structured home-based rehabilitation programs to promote self-care in older adults and health-related outcomes among people aged 60 years or older. Following the Preferred Reporting Items for Systematic…
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rabindra.tharu.np@gmail.com
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Causal relationships between immune cells, inflammatory factors, serum metabolites, and hepatic cancer: A two-sample Mendelian randomization study
BACKGROUND Observational studies and clinical trials suggest associations between immune cells, inflammatory factors, serum metabolites, and hepatic cancer. However, the causal relationships between these factors and hepatic cancer remain to be established. OBJECTIVE To explore the causal relationships between immune cells, inflammatory factors, serum metabolites, and hepatic cancer. METHODS This study employed comprehensive two-sample Mendelian…
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rabindra.tharu.np@gmail.com
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Influence of IoT implementation on Resource management in construction
The desire to increase resource management efficacy in the construction sector is expanding because of measures to reduce costs, boost productivity, and minimize environmental impact. The Internet of Things (IoT) has the potential to alter resource management in the construction sector by delivering real-time data and insights that may assist decision-makers in optimizing resource allocation…
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rabindra.tharu.np@gmail.com
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8-Aminoquinoline derived two Schiff base platforms: Synthesis, characterization, DFT insights, corrosion inhibitor, molecular docking, and pH-dependent antibacterial study
The current research divulges the synthesis of two new Schiff base (SB) ( / ) derived from 8-aminoquinoline (8-AMQ) in the presence of 2-hydroxy naphthaldehyde (NAPH) and ortho-vanillin (O-VAN) in CHOH solvent. They are structurally characterized by spectroscopic methods (IR/Raman/UV-vis/DRS/NMR) and SEM-EDX. SB compounds have a biologically active avenue of azomethine/imine group (H-C=N) that can…
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rabindra.tharu.np@gmail.com
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Mechanism investigation of anti-NAFLD of Shugan Yipi Granule based on network pharmacology analysis and experimental verification
As a classical traditional Chinese patent medicine, Shugan Yipi Granule is widely used in China to treat non-alcoholic fatty liver disease (NAFLD) recently. Our previous study confirmed that Shugan Yipi Granule are effective in NAFLD. However, its underlying mechanism is still unknown. This study aims to investigate the mechanism of Shugan Yipi Granule on NAFLD…
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rabindra.tharu.np@gmail.com
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Lifestyle, air pollution, and risk of multimorbidity in a prospective analysis of the UK Biobank cohort
BACKGROUND Although associations between chronic obstructive pulmonary disease (COPD) or ischaemic heart disease (IHD) and lifestyle factors or air pollution factors (referred as LAFs below) are well-established, it is unclear the influences of LAFs on the trajectory of IHD and COPD multimorbidity (referred as ICM below). Therefore, this study investigated the influences of LAFs on…
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rabindra.tharu.np@gmail.com
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The relationship between anxiety and depression in adolescent depression patients: The mediating effect of hope level and coping modes
BACKGROUND Adolescents diagnosed with depression are particularly susceptible to anxiety and depressive symptoms, this vulnerability often diminishes their future expectations and overall outlook on life. The objective of this research was to scrutinize the associated risk factors of adolescent depression and delineated the interplay between anxiety and depressive symptoms. Concurrently, it sought to ascertain the…
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rabindra.tharu.np@gmail.com
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Antidiabetic potentials of crude and purified sulphated polysaccharides isolated from Gracilaria gracilis, a seaweed from South Africa
Over 90 % of all cases of diabetes that have been diagnosed are type 2 diabetes (T2D), a disease exacerbated by an increase in sedentary behaviour, bad eating habits, and obesity. This study investigated the antidiabetic properties of , using and experimental models. The sulphated polysaccharides (SPs) from crude extracts of the seaweed powder was prepared…
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rabindra.tharu.np@gmail.com
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Identification of diagnostic biomarkers of rheumatoid arthritis based on machine learning-assisted comprehensive bioinformatics and its correlation with immune cells
BACKGROUND Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease characterized by inflammatory cell infiltration, which can lead to chronic disability, joint destruction and loss of function. At present, the pathogenesis of RA is still unclear. The purpose of this study is to explore the potential biomarkers and immune molecular mechanisms of rheumatoid arthritis through…
