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rabindra.tharu.np@gmail.com
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Prediction of clear cell renal cell carcinoma prognosis based on an immunogenomic landscape analysis
Immune cell infiltration and tumor-related immune molecules play key roles in tumorigenesis and tumor progression. The influence of immune interactions on the molecular characteristics and prognosis of clear cell renal cell carcinoma (ccRCC) remains unclear. A machine learning algorithm was applied to the transcriptome data from The Cancer Genome Atlas database to determine the immunophenotypic…
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rabindra.tharu.np@gmail.com
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Seasonal variations in soil characteristics control microbial respiration and carbon use under tree plantations in the middle gangetic region
Seasonal variations directly impact the biochemical and microbial properties of the soil, influence carbon and nutrient cycling within the soil system. Soils under tree plantation (TP) are rich in organic matter and microbial population, making them more susceptible to seasonal variation. We studied the effect of seasonal variations in soil chemical properties (pH, electrical conductivity…
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rabindra.tharu.np@gmail.com
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Berberine suppressed the epithelial-mesenchymal transition (EMT) of colon epithelial cells through the TGF-β1/Smad and NF-κB pathways associated with miRNA-1269a
OBJECTIVE To explore the mechanisms of the TGF-β1/Smad and NF-κB pathways in the effect of berberine (BBR) on colon cancer epithelial-mesenchymal transition (EMT) and their regulatory relationships with microRNAs (miRNAs). METHODS TGF-β1 was used to induce EMT in normal colon epithelial HCoEpiC cells and colon cancer HT29 cells in vitro. After BBR intervention, the expression of…
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rabindra.tharu.np@gmail.com
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Effect of alkali treatment on mechanical and water absorption properties of biodegradable wheat-straw/glass fiber reinforced epoxy hybrid composites: A sustainable alternative for conventional materials
Fiber-reinforced polymer composites are preferred over conventional materials because of their superior strength and modulus. Previously limited due to high manufacturing costs, synthetic fibers have been replaced by some natural fibers, such as waste wheat straw fibers. Here, epoxy-based polymer composites’ mechanical and physical properties have been investigated, focusing on fiber weight ratios for both…
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rabindra.tharu.np@gmail.com
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Association between serum total bilirubin with Parkinson’s disease among American adults (NHANES 1999 to 2018)
BACKGROUND Currently, the existing evidence on the correlation between serum total bilirubin (STB) and Parkinson’s disease (PD) is insufficient. The objective of this study was to clarify the relationship between STB levels and PD within the US (United States) population. METHODS A cross-sectional analysis was conducted using data from 25,637 participants in the National Health…
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rabindra.tharu.np@gmail.com
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Soil properties and nutrient uptake of maize (Zea mays) as influenced by mixed manure and blended inorganic fertilizer in Haramaya district, eastern Ethiopia
The deteriorating state of soil fertility and low agricultural productivity in Ethiopia can be traced to the lack of equivalent consideration given to the soil’s biological, chemical, and physical properties. A pot experiment was conducted to investigate the effect of mixed manure and blended nitrogen, phosphorus, sulfur and boron (NPSB) fertilizer on phosphorus adsorption, and…
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rabindra.tharu.np@gmail.com
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Investigating the effects of hydrostatic pressure on the physical properties of cubic Sr(3)BCl(3) (B = As, Sb) for improved optoelectronic applications: A DFT study
This article explores changes in the structural, electronic, elastic, and optical properties of the novel cubic SrBCl (B = As, Sb) with increasing pressure. This research aims to decrease the electronic band gap of SrBCl (B = As, Sb) by applying pressure, with the objective of enhancing the optical properties and evaluating the potential of…
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rabindra.tharu.np@gmail.com
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A Fractional Order-Kepler Optimization Algorithm (FO-KOA) for single and double-diode parameters PV cell extraction
The primary objective of this study is to investigate the effects of the Fractional Order Kepler Optimization Algorithm (FO-KOA) on photovoltaic (PV) module feature identification in solar systems. Leveraging the strengths of the original KOA, FO-KOA introduces fractional order elements and a Local Escaping Approach (LEA) to enhance search efficiency and prevent premature convergence. The…
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rabindra.tharu.np@gmail.com
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Role of bronchoscopy in the management of patients with suspected or suffering from ventilator-associated pneumonia: A meta-analysis
BACKGROUND The utility of bronchoscopy in the treatment of patients with ventilator-associated pneumonia (VAP) has been proposed, although prior research has yielded inconclusive findings. This systematic review and meta-analysis were conducted to examine the impact of bronchoscopy on mortality rates, duration of mechanical ventilation (MV), and length of stay in the intensive care unit (ICU)…
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rabindra.tharu.np@gmail.com
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Ethnobotanical study of medicinal plants used to manage human ailments in Lay Gaint District, South Gondar Zone, Amhara Region, Northwestern Ethiopia
The aim of this work is to document and record the use of medicinal plants to treat various ailments in the study area. A total of 84 informants, consisting of 54 men and 30 women, between 35 and 80 years of age were chosen. Additionally, 20 key informants were deliberately selected for their expertise. Data…
