-
rabindra.tharu.np@gmail.com
·
Defective TiO(x) overlayers catalyze propane dehydrogenation promoted by base metals
The industrial catalysts utilized for propane dehydrogenation (PDH) to propylene, an important alternative to petroleum-based cracking processes, either use expensive metals or metal oxides that are environmentally unbenign. We report that a typically less-active oxide, titanium oxide (TiO), can be combined with earth-abundant metallic nickel (Ni) to form an unconventional Ni@TiO catalyst for efficient PDH.…
-
rabindra.tharu.np@gmail.com
·
The human mitochondrial mRNA structurome reveals mechanisms of gene expression
The human mitochondrial genome encodes crucial oxidative phosphorylation system proteins, pivotal for aerobic energy transduction. They are translated from nine monocistronic and two bicistronic transcripts whose native structures remain unexplored, posing a gap in understanding mitochondrial gene expression. In this work, we devised the mitochondrial dimethyl sulfate mutational profiling with sequencing (mitoDMS-MaPseq) method and applied…
-
rabindra.tharu.np@gmail.com
·
Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program
One of the justifiable criticisms of human genetic studies is the underrepresentation of participants from diverse populations. Lack of inclusion must be addressed at-scale to identify causal disease factors and understand the genetic causes of health disparities. We present genome-wide associations for 2068 traits from 635,969 participants in the Department of Veterans Affairs Million Veteran…
-
rabindra.tharu.np@gmail.com
·
Sculpting conducting nanopore size and shape through de novo protein design
Transmembrane β-barrels have considerable potential for a broad range of sensing applications. Current engineering approaches for nanopore sensors are limited to naturally occurring channels, which provide suboptimal starting points. By contrast, de novo protein design can in principle create an unlimited number of new nanopores with any desired properties. Here we describe a general approach…
-
rabindra.tharu.np@gmail.com
·
The benefits of GLP-1 drugs beyond obesity
Glucagon-like peptide-1-based medicines have weight loss-independent actions.
-
rabindra.tharu.np@gmail.com
·
Ph(3)PCN(2): A stable reagent for carbon-atom transfer
Precise modification of a chemical site in a molecule at the single-atom level is one of the most elegant yet difficult transformations in chemistry. A reagent specifically designed for chemoselective introduction of monoatomic carbon is a particularly formidable challenge. Here, we report a straightforward, azide-free synthesis of a crystalline and isolable diazophosphorus ylide, PhPCN, a…
-
rabindra.tharu.np@gmail.com
·
Mutant IDH1 inhibition induces dsDNA sensing to activate tumor immunity
() is the most commonly mutated metabolic gene across human cancers. Mutant IDH1 (mIDH1) generates the oncometabolite (R)-2-hydroxyglutarate, disrupting enzymes involved in epigenetics and other processes. A hallmark of -mutant solid tumors is T cell exclusion, whereas mIDH1 inhibition in preclinical models restores antitumor immunity. Here, we define a cell-autonomous mechanism of mIDH1-driven immune evasion.…
-
rabindra.tharu.np@gmail.com
·
Recurrent gene flow between Neanderthals and modern humans over the past 200,000 years
Although it is well known that the ancestors of modern humans and Neanderthals admixed, the effects of gene flow on the Neanderthal genome are not well understood. We develop methods to estimate the amount of human-introgressed sequences in Neanderthals and apply it to whole-genome sequence data from 2000 modern humans and three Neanderthals. We estimate…
-
rabindra.tharu.np@gmail.com
·
Unsupervised evolution of protein and antibody complexes with a structure-informed language model
Large language models trained on sequence information alone can learn high-level principles of protein design. However, beyond sequence, the three-dimensional structures of proteins determine their specific function, activity, and evolvability. Here, we show that a general protein language model augmented with protein structure backbone coordinates can guide evolution for diverse proteins without the need to…
-
rabindra.tharu.np@gmail.com
·
Evolution and host-specific adaptation of Pseudomonas aeruginosa
The major human bacterial pathogen causes multidrug-resistant infections in people with underlying immunodeficiencies or structural lung diseases such as cystic fibrosis (CF). We show that a few environmental isolates, driven by horizontal gene acquisition, have become dominant epidemic clones that have sequentially emerged and spread through global transmission networks over the past 200 years. These…
