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rabindra.tharu.np@gmail.com
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An atlas of transcribed enhancers across helper T cell diversity for decoding human diseases
Transcribed enhancer maps can reveal nuclear interactions underpinning each cell type and connect specific cell types to diseases. Using a 5′ single-cell RNA sequencing approach, we defined transcription start sites of enhancer RNAs and other classes of coding and noncoding RNAs in human CD4 T cells, revealing cellular heterogeneity and differentiation trajectories. Integration of these…
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rabindra.tharu.np@gmail.com
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A photoluminescent hydrogen-bonded biomass aerogel for sustainable radiative cooling
Passive radiant cooling is a potentially sustainable thermal management strategy amid escalating global climate change. However, petrochemical-derived cooling materials often face efficiency challenges owing to the absorption of sunlight. We present an intrinsic photoluminescent biomass aerogel, which has a visible light reflectance exceeding 100%, that yields a large cooling effect. We discovered that DNA and…
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rabindra.tharu.np@gmail.com
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Trigeminal ganglion neurons are directly activated by influx of CSF solutes in a migraine model
Classical migraine patients experience aura, which is transient neurological deficits associated with cortical spreading depression (CSD), preceding headache attacks. It is not currently understood how a pathological event in cortex can affect peripheral sensory neurons. In this study, we show that cerebrospinal fluid (CSF) flows into the trigeminal ganglion, establishing nonsynaptic signaling between brain and…
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rabindra.tharu.np@gmail.com
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Genomic investigation of 18,421 lines reveals the genetic architecture of rice
Understanding how numerous quantitative trait loci (QTL) shape phenotypic variation is an important question in genetics. To address this, we established a permanent population of 18,421 (18K) rice lines with reduced population structure. We generated reference-level genome assemblies of the founders and genotyped all 18K-rice lines through whole-genome sequencing. Through high-resolution mapping, 96 high-quality candidate…
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rabindra.tharu.np@gmail.com
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An intron endonuclease facilitates interference competition between coinfecting viruses
Introns containing homing endonucleases are widespread in nature and have long been assumed to be selfish elements that provide no benefit to the host organism. These genetic elements are common in viruses, but whether they confer a selective advantage is unclear. In this work, we studied intron-encoded homing endonuclease gp210 in bacteriophage ΦPA3 and found…
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rabindra.tharu.np@gmail.com
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A molecular glue degrader of the WIZ transcription factor for fetal hemoglobin induction
Sickle cell disease (SCD) is a prevalent, life-threatening condition attributable to a heritable mutation in β-hemoglobin. Therapeutic induction of fetal hemoglobin (HbF) can ameliorate disease complications and has been intently pursued. However, safe and effective small-molecule inducers of HbF remain elusive. We report the discovery of dWIZ-1 and dWIZ-2, molecular glue degraders of the WIZ…
