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rabindra.tharu.np@gmail.com
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Update to: Study Pre-protocol for “BronchStart – The Impact of the COVID-19 Pandemic on the Timing, Age and Severity of Respiratory Syncytial Virus (RSV) Emergency Presentations; a Multi-Centre Prospective Observational Cohort Study”
BACKGROUND In 2021 we launched the BronchStart study, which collected information on 17,899 presentations in children with serious respiratory tract infections following the release of lockdown restrictions. Our study informed the Joint Committee on Vaccination and Immunisation’s decision to recommend the introduction maternal respiratory syncytial virus (RSV) vaccination, which was introduced in the United Kingdom…
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rabindra.tharu.np@gmail.com
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A DNA barcoding framework for taxonomic verification in the Darwin Tree of Life Project
Biodiversity genomics research requires reliable organismal identification, which can be difficult based on morphology alone. DNA-based identification using DNA barcoding can provide confirmation of species identity and resolve taxonomic issues but is rarely used in studies generating reference genomes. Here, we describe the development and implementation of DNA barcoding for the Darwin Tree of Life…
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rabindra.tharu.np@gmail.com
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The genome sequence of the beech bark beetle, Taphrorychus bicolor (Herbst, 1793)
We present a genome assembly from an individual male (the beech bark beetle; Arthropoda; Insecta; Coleoptera; Curculionidae). The genome sequence is 575.2 megabases in span. Most of the assembly is scaffolded into 12 chromosomal pseudomolecules, including the X and Y sex chromosomes. The mitochondrial genome has also been assembled and is 15.46 kilobases in length.…
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rabindra.tharu.np@gmail.com
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The genome sequence of the hawthorn leaf beetle, Lochmaea crataegi (Forster, 1771)
We present a genome assembly from an individual male (the hawthorn leaf beetle; Arthropoda; Insecta; Coleoptera; Chrysomelidae). The genome sequence is 891.3 megabases in span. Most of the assembly is scaffolded into 16 chromosomal pseudomolecules, including the X and Y sex chromosomes. The mitochondrial genome has also been assembled and is 18.32 kilobases in length.
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rabindra.tharu.np@gmail.com
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Genome-wide association study of susceptibility to hospitalised respiratory infections
: Globally, respiratory infections contribute to significant morbidity and mortality. However, genetic determinants of respiratory infections are understudied and remain poorly understood. : We conducted a genome-wide association study in 19,459 hospitalised respiratory infection cases and 101,438 controls from UK Biobank (Stage 1). We followed-up well-imputed top signals from our Stage 1 analysis in 50,912…
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rabindra.tharu.np@gmail.com
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A feasibility study of controlled human infection with intradermal Bacillus Calmette-Guérin (BCG) injection: Pilot BCG controlled human infection model
Tuberculosis (TB) caused 1.5 million deaths in 2020, making it the leading infectious killer after COVID-19. Bacille Calmette-Guerin (BCG) is the only licensed vaccine against TB but has sub-optimal efficacy against pulmonary TB and reduced effectiveness in regions close to the equator with high burden. Efforts to find novel vaccines are hampered due to the…
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rabindra.tharu.np@gmail.com
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COPO – Managing sample metadata for biodiversity: considerations from the Darwin Tree of Life project
Large-scale reference genome sequencing projects for all of biodiversity are underway and common standards have been in place for some years to enable the understanding and sharing of sequence data. However, the metadata that describes the collection, processing and management of samples, and link to the associated sequencing and genome data, are not yet adequately…
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rabindra.tharu.np@gmail.com
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The genome sequence of a heart cockle, Fragum fragum (Linnaeus, 1758)
We present a genome assembly from an individual specimen of (a heart cockle; Mollusca; Bivalvia; Veneroida; Cardiidae). The genome sequence is 1,153.1 megabases in span. Most of the assembly is scaffolded into 19 chromosomal pseudomolecules. The mitochondrial genome has also been assembled and is 22.36 kilobases in length. Gene annotation of this assembly on Ensembl…
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rabindra.tharu.np@gmail.com
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Prevalence of different types of interproximal contacts in the permanent dentition – a study cast evaluation
BACKGROUND A new classification called OXIS was proposed for categorizing the interproximal contacts of primary molars, modified for the primary canines and its prevalence was established. No such information is available for the permanent dentition. Hence, the aim was to establish the variations in interproximal contacts of the permanent dentition and thereby modify the OXIS…
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rabindra.tharu.np@gmail.com
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The associations between religious/spiritual beliefs and behaviours and study participation in a prospective cohort study (ALSPAC) in Southwest England
BACKGROUND Longitudinal studies are key to understanding risk factors for health, well-being, and disease, yet associations may be biased if study invitation and participation are non-random. Religious/spiritual beliefs and behaviours (RSBB) are increasingly recognised as having potentially important relationships with health. However, it is unclear whether RSBB is associated with study participation. We examine whether…
