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Update to: Study Pre-protocol for “BronchStart – The Impact of the COVID-19 Pandemic on the Timing, Age and Severity of Respiratory Syncytial Virus (RSV) Emergency Presentations; a Multi-Centre Prospective Observational Cohort Study”

Affiliations
  • 1Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.
  • 2Centre for Inflammation Research, University of Edinburgh, Edinburgh, UK.
  • 3Department of Paediatric Respiratory and Sleep Medicine, Royal Hospital for Children and Young People, Edinburgh, UK.
  • 4Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK.
  • 5NIHR Oxford Biomedical Research Centre, Oxford, UK.
  • 6Wellcome-Wolfson Institute for Experimental Medicine at Queen’s University Belfast, Belfast, UK.
  • 7Department of Anthropology, University College London, London, UK.
  • 8Faculty of Health and Applied Sciences, University of the West of England, Bristol, UK.
  • 9Emergency Department, Bristol Royal Hospital for Children, Bristol, UK.
  • 10Bristol Royal Hospital for Children, Bristol, UK.
  • 11University of Liverpool Medical School, Liverpool, UK.
  • 12Department of Child Life and Health, University of Edinburgh, Edinburgh, UK.
  • 13University of Liverpool, Liverpool, UK.
  • 14Alder Hey Children’s Hospital, Liverpool, UK.
  • 15Department of Paediatric Infectious Diseases and Immunology, Royal Hospital for Children, Glasgow, UK.
  • 16Paediatric Emergency Medicine Leicester Academic (PEMLA) Group, Leicester Royal Infirmary, Leicester, UK.
  • 17Sapphire Group, Health Sciences, Leicester University, University of Leicester, UK.

Published on:

February 11, 2025

Abstract

BACKGROUND

In 2021 we launched the BronchStart study, which collected information on 17,899 presentations in children with serious respiratory tract infections following the release of lockdown restrictions. Our study informed the Joint Committee on Vaccination and Immunisation’s decision to recommend the introduction maternal respiratory syncytial virus (RSV) vaccination, which was introduced in the United Kingdom in August/September 2024.

STUDY QUESTION

We modified our original protocol to conduct a United Kingdom-wide assessment of maternal vaccination against RSV.

METHODS AND LIKELY IMPACT

We will conduct a multi-centre study, utilising the PERUKI network used in the original BronchStart study, to assess the effectiveness of maternal vaccination using a test-negative study design. We will gather detailed clinical information on children admitted with bronchiolitis in the post-RSV vaccination era, and understand possible reasons for incomplete vaccine uptake.

Keywords:

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