Contact Us

A fair individualized polysocial risk score for identifying increased social risk in type 2 diabetes

Affiliations
  • 1Department of Health Outcomes and Biomedical Informatics, University of Florida, Gainesville, FL, USA.
  • 2Department of Pharmaceutical Outcomes and Policy, University of Florida, Gainesville, FL, USA.
  • 3Division of Endocrinology, Diabetes and Metabolism, College of Medicine, University of Florida, Gainesville, FL, USA.
  • 4Department of Surgery, College of Medicine- Jacksonville, University of Florida, Jacksonville, FL, USA.
  • 5Department of Community Health and Family Medicine, College of Medicine, University of Florida, Jacksonville, FL, USA.
  • 6Division of General Internal Medicine, Department of Medicine, College of Medicine, University of Florida, Gainesville, FL, USA.
  • 7Department of Health Outcomes and Biomedical Informatics, University of Florida, Gainesville, FL, USA. bianjiang@ufl.edu.

Published on:

October 5, 2024

Abstract

Racial and ethnic minorities bear a disproportionate burden of type 2 diabetes (T2D) and its complications, with social determinants of health (SDoH) recognized as key drivers of these disparities. Implementing efficient and effective social needs management strategies is crucial. We propose a machine learning analytic pipeline to calculate the individualized polysocial risk score (iPsRS), which can identify T2D patients at high social risk for hospitalization, incorporating explainable AI techniques and algorithmic fairness optimization. We use electronic health records (EHR) data from T2D patients in the University of Florida Health Integrated Data Repository, incorporating both contextual SDoH (e.g., neighborhood deprivation) and person-level SDoH (e.g., housing instability). After fairness optimization across racial and ethnic groups, the iPsRS achieved a C statistic of 0.71 in predicting 1-year hospitalization. Our iPsRS can fairly and accurately screen patients with T2D who are at increased social risk for hospitalization.

Related Concept Videos

JoVE Research Video for Diabetes Mellitus: Type 2 and Gestational 01:22

1.8K

Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the…

JoVE Research Video for Diabetes Mellitus: Overview and Type I Subtype 01:22

2.0K

Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with…

JoVE Research Video for Diabetes: Symptoms, Diagnosis, and Complications 01:15

301

For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is…

JoVE Research Video for Carbohydrate Metabolism 01:36

9.7K

Carbohydrates are polymers composed of molecules containing atoms of carbon, hydrogen and oxygen. One gram of carbohydrate can provide four kilo-calories of energy, which makes it the most efficient instant energy source.
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in…

JoVE Research Video for Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches 01:23

76

Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,…

JoVE Research Video for Pathophysiology of Diabetes 01:20

445

Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,…