Acute Lymphoblastic Leukemia, Version 2.2024, NCCN Clinical Practice Guidelines in Oncology

Affiliations
  • 1Moffitt Cancer Center.
  • 2University of Wisconsin Carbone Cancer Center.
  • 3Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine.
  • 4Fox Chase Cancer Center.
  • 5City of Hope National Medical Center.
  • 6University of Michigan Rogel Cancer Center.
  • 7Dana-Farber/Brigham and Women’s Cancer Center.
  • 8Robert H . Lurie Comprehensive Cancer Center of Northwestern University.
  • 9Mass General Cancer Center.
  • 10Fred Hutchinson Cancer Center.
  • 11Fred & Pamela Buffett Cancer Center.
  • 12The University of Texas MD Anderson Cancer Center.
  • 13UC Davis Comprehensive Cancer Center.
  • 14Duke Cancer Institute.
  • 15Stanford Cancer Institute.
  • 16Mayo Clinic Comprehensive Cancer Center.
  • 17UCSF Helen Diller Family Comprehensive Cancer Center.
  • 18The Ohio State University Comprehensive Cancer Center.
  • 19Abramson Cancer Center at the University of Pennsylvania.
  • 20UC San Diego Moores Cancer Center.
  • 21Yale Cancer Center/Smilow Cancer Hospital.
  • 22UCLA Jonsson Comprehensive Cancer Center.
  • 23Vanderbilt-Ingram Cancer Center.
  • 24Memorial Sloan Kettering Cancer Center.
  • 25Roswell Park Comprehensive Cancer Center.
  • 26O’Neal Comprehensive Cancer Center at UAB.
  • 27The UChicago Medicine Comprehensive Cancer Center.
  • 28University of Colorado Cancer Center.
  • 29Huntsman Cancer Institute at the University of Utah.
  • 30Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute.
  • 31Johns Hopkins Kimmel Cancer Center.
  • 32National Comprehensive Cancer Network.

Published on:

Abstract

The NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for acute lymphoblastic leukemia (ALL) provide recommendations for management of ALL, with a focus on the classification of ALL subtypes based on immunophenotype and cytogenetic/molecular markers; risk assessment and stratification for risk-adapted therapy; treatment strategies for Philadelphia chromosome (Ph)-positive and Ph-negative ALL for both adolescent and young adult and adult patients; and supportive care considerations. This selection from the NCCN Guidelines for ALL focuses on treatment recommendations for adults with newly diagnosed Ph-negative ALL based on current evidence.