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H(2)O(2) sulfenylates CHE, linking local infection to the establishment of systemic acquired resistance

Affiliations
  • 1Department of Biology, Duke University, Durham, NC, 27708, USA.
  • 2Howard Hughes Medical Institute, Duke University, Durham, NC, 27708, USA.

Published on:

September 12, 2024

Abstract

In plants, a local infection can lead to systemic acquired resistance (SAR) through increased production of salicylic acid (SA). For many years, the identity of the mobile signal and its direct transduction mechanism for systemic SA synthesis in initiating SAR have been debated. We found that in , after a local infection, the conserved cysteine residue of the transcription factor CCA1 HIKING EXPEDITION (CHE) undergoes sulfenylation in systemic tissues, which enhances its binding to the promoter of the SA-synthesis gene () and increases SA production. Furthermore, hydrogen peroxide (HO) produced through NADPH oxidases is the mobile signal that sulfenylates CHE in a concentration-dependent manner. Accumulation of SA and the previously reported signal molecules, such as -hydroxypipecolic acid (NHP), then form a signal amplification loop to establish SAR.

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