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rabindra.tharu.np@gmail.com
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Menin inhibitors in the treatment of acute myeloid leukemia
Acute myeloid leukemia (AML) is a heterogeneous hematologic malignancy characterized by the (oligo)clonal expansion of myeloid progenitor cells. Despite advances in treatment, AML remains challenging to cure, particularly in patients with specific genetic abnormalities. Menin inhibitors have emerged as a promising therapeutic approach, targeting key genetic drivers of AML such as KMT2A rearrangements and NPM1…
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rabindra.tharu.np@gmail.com
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How I Treat AML relapse after allogeneic HCT
Allogeneic hematopoietic stem-cell transplantation (HCT) is one of the principal curative approaches in the treatment of acute myeloid leukemia (AML); however, relapse post-transplantation remains a catastrophic event with poor prognosis. The incidence of relapse has remained unchanged over the last three decades despite an evolving understanding of the immunobiology of the graft-versus leukemia effect and…
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rabindra.tharu.np@gmail.com
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A pilot study of transcriptomic preimplantation genetic testing (PGT-T): towards a new step in embryo selection?
STUDY QUESTION Is it possible to predict an euploid chromosomal constitution and identify a transcriptomic profile compatible with extended embryonic development from RNA sequencing (RNA-Seq) data? SUMMARY ANSWER It has been possible to obtain a karyotype comparable to preimplantation genetic testing for aneuploidy (PGT-A), in addition to a transcriptomic signature of embryos which might be…
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rabindra.tharu.np@gmail.com
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Biosimilars versus the originator of follitropin alfa for ovarian stimulation in ART: a systematic review and meta-analysis
STUDY QUESTION Is the probability of pregnancy different between women using biosimilars versus the originator of follitropin alfa for ovarian stimulation in ART? SUMMARY ANSWER Meta-analysis of eight randomized clinical trials (RCTs) suggests that live birth, clinical, and ongoing pregnancy rates are significantly lower with biosimilars of follitropin alfa compared to the originator. WHAT IS…
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rabindra.tharu.np@gmail.com
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Self-reported diagnoses of dietary allergens and fecundability in a North American cohort
STUDY QUESTION To what extent are self-reported diagnoses of food allergies associated with fecundability, the per-cycle probability of conception? SUMMARY ANSWER Fecundability was not appreciably associated with self-reported food allergy diagnoses, number of food allergies, age at first diagnosis, or time since last allergic reaction. WHAT IS KNOWN ALREADY Food allergies are atopic diseases that…
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rabindra.tharu.np@gmail.com
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Iron-Assisted and Cu-Mediated Direct Aminocarbonylation of Nitroarene with Boronic Acid
Herein, we have established the formation of diaryl amide by aminocarbonylation of nitrobenzene with boronic acids. The method works in the catalytic presence of economical and commercially available CuI salt, which was significantly promoted by the FeSe(CO) cluster. Mo(CO) serves as a source of CO, and it also acts as a reductant with a combination…
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rabindra.tharu.np@gmail.com
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Microplasma Controlled Nanogold Sensor for SERS of Aliphatic and Aromatic Explosives with PCA-KNN Recognition
Nanogold is an emerging material for enhancing surface-enhanced Raman scattering (SERS), which enables the detection of hazardous analytes at trace levels. This study presents a simple, single-step plasma synthesis method to control the size and yield of Au nanoparticles by using plasma-liquid redox chemistry. The pin-based argon plasma reduces the Au precursor in under 5…
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rabindra.tharu.np@gmail.com
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Identification of plasma protein biomarkers for endometriosis and the development of statistical models for disease diagnosis
STUDY QUESTION Can a panel of plasma protein biomarkers be identified to accurately and specifically diagnose endometriosis? SUMMARY ANSWER A novel panel of 10 plasma protein biomarkers was identified and validated, demonstrating strong predictive accuracy for the diagnosis of endometriosis. WHAT IS KNOWN ALREADY Endometriosis poses intricate medical challenges for affected individuals and their physicians,…
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rabindra.tharu.np@gmail.com
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The cytokinin efflux transporter ABCC4 participates in Arabidopsis root system development
The directional and sequential flow of cytokinin in plants is organized by a complex network of transporters. Genes involved in several aspects of cytokinin transport have been characterized; however, much of the elaborate system remains elusive. In this study, we used a transient expression system in tobacco (Nicotiana benthamiana) leaves to screen Arabidopsis (Arabidopsis thaliana)…
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rabindra.tharu.np@gmail.com
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Race, homosexuality, and AIDS in London: the response of British AIDS voluntary organizations to Black gay men’s sexual health needs during the AIDS crisis (1980s-2000)
Focusing on three specific organizations-The Terrence Higgins Trust (THT), Blackliners, and The NAZ Project (Naz)-this article explores the different ways in which voluntary organizations responded to Black gay men (BGM) in Britain during the AIDS crisis from the 1980s to 2000. Illustrating how the place of BGM in Britain at this time was multidimensional and…
