矿物甲基皮质类高血压
1Department of Medicine, Queen Elizabeth Hospital, Edgbaston, Birmingham, UK. p.m.stewart@bham.ac.uk
Lancet (London, England)
|April 28, 1999
概括
矿物甲基皮质激素高血压是高血压的可逆原因,包括原发性阿尔多斯特隆症和罕见的遗传性疾病. 在高血压患者,低或家族病史的早期查至关重要.
科学领域:
- 内分泌学 在内分泌学.
- 腎臟病學 (nephrology) 是一種醫學專業.
- 心血管医学 心血管医学
背景情况:
- 矿物皮质性高血压,以高血压,低和抑制的素为特征,是一种被诊断不足的疾病.
- 它代表了高血压的潜在可逆原因,通常被误认为是基本高血压.
- 主要的阿尔多斯特是最常见的原因,但单一的形式也存在.
研究的目的:
- 要突出矿物质皮质类高血压作为高血压的可逆原因的重要性.
- 讨论区分原发性阿尔多斯顿主义亚型的诊断方法.
- 强调需要增加临床怀疑和查矿物质皮质类高血压的必要性.
主要方法:
- 诊断评估涉及对照的姿势研究,以测量血内活性和阿尔多斯特度.
- 上腺成像有助于区分生产阿尔多素的腺瘤和异常性上腺增生.
- 基因分析用于诊断单基因形式,如可抑制葡萄糖皮质激素的超阿尔多斯特隆症,利德尔综合征和明显的矿物质皮质激素过量.
主要成果:
- 控制姿势研究和成像有效地区分生产阿尔多素的腺瘤和异常性上腺增生在大多数原发性阿尔多素症病例中.
- 单一的形式提供了关于矿物质皮质激素激素作用的见解.
- 有相当数量的矿物质皮质类高血压患者呈现正常血清水平.
结论:
- 包括初级阿尔多斯特和单一性形式在内的矿物质皮质类高血压需要在所有高血压患者中高度怀疑指数.
- 推对高血压患者进行查,包括低血压,严重高血压或家族史上的高血压或中风.
- 早期识别和管理可以导致可逆的血压控制.
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