类药物通过特定的炎症途径促进强大的全身抗氧化作用.
Mehdi H Shishehbor1, Marie-Luise Brennan, Ronnier J Aviles
1Department of Cell Biology, and Center for Cardiovascular Diagnostics and Prevention, Cleveland Clinic Foundation, 9500 Euclid Ave, NC10, Cleveland, Ohio 44195, USA.
Circulation
|July 16, 2003
概括
类药物降低了关键的氧化应激标志物,包括甲和甲 (NO2Tyr),这表明它具有强大的全身抗氧化作用. 这些发现表明,他类药物可以通过抑制特定的氧化途径来对抗动脉样硬化.
科学领域:
- 生物化学 生物化学
- 心血管医学 心血管医学
- 药理学 药理学是指药理学的学科.
背景情况:
- 甲基甲基CoA减少酶抑制剂 (他类药物) 具有抗炎和抗氧化特性.
- 以前的研究表明,他类药物降低了氧化物衍生的氧化剂的标记物二氧化 (NO2Tyr) 的血含量.
- 在体内,他类药物对其他氧化应激途径的影响仍未得到研究.
研究的目的:
- 研究阿托瓦斯塔丁在高胆固醇血症患者中对各种氧化应激标志物的作用.
- 为了确定他类药物治疗是否抑制了除氧化物衍生氧化剂之外的明显的氧化途径.
主要方法:
- 没有冠状动脉疾病的高胆固醇血症患者接受阿托瓦斯塔丁 (10毫克/天) 治疗12周.
- 使用质谱法量化了二,NO2Tyr,dityrosine和orthotyrosine的血水平.
- 还评估了脂蛋白水平和C-反应蛋白.
主要成果:
- 阿托瓦斯塔丁显著降低了分别为30%,25%和32%的,NO2Tyr和dityrosine水平 (P<0.02).
- 这些降低与总胆固醇和阿波利波蛋白B-100的降低相当.
- 没有观察到甲状腺氨酸或C反应蛋白水平的显著变化.
结论:
- 类他类药物通过抑制不同的氧化途径,产生显著的全身抗氧化作用.
- 抑制的途径包括涉及由髓氧化酶衍生和氧化物衍生氧化剂的途径,涉及到动脉生成.
- 这些发现提供了关于他类药物的有益心血管作用和潜在的监测策略的见解.
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