不准确的方法是否掩盖了脂肪和乳腺癌之间的关系?
Sheila A Bingham1, Robert Luben, Ailsa Welch
1MRC Dunn Human Nutrition Unit, Welcome Trust/MRC Building, Hills Road, CB2 2XY, Cambridge, UK. sab@mrc-dunn.cam.ac.uk <sab@mrc-dunn.cam.ac.uk>
Lancet (London, England)
|July 30, 2003
概括
饮食中的脂肪摄入量,特别是和脂肪,当准确测量时,与乳腺癌风险增加有关. 食品频率调查问卷可能会低估这种关联,因为测量错误.
科学领域:
- 营养科学 营养科学
- 流行病学 流行病学
- 在瘤学瘤学.
背景情况:
- 以前对队列研究的综合分析发现,脂肪摄入量与乳腺癌风险之间没有关联.
- 在这些研究中使用的食品频率问卷 (FFQ) 容易产生显著的测量误差.
研究的目的:
- 用FFQ和详细的食物日记来调查饮食脂肪摄入量与乳腺癌风险之间的关联.
- 评估饮食测量误差对脂肪消耗与乳腺癌发病率之间观察到的关系的影响.
主要方法:
- 一组13,070名妇女在1993-1997年期间通过FFQ和7天的食物日记提供了饮食数据.
- 在2000年之前诊断的168例乳腺癌病例与四个匹配的对照组进行了比较.
- 分析了饮食摄入量,特别是和脂肪,其与乳腺癌风险的关联.
主要成果:
- 通过食物日记测量的和脂肪摄入量显示出与乳腺癌风险增加的显著关联 (HR 1.22每五分位数增加,p=0.005).
- 通过FFQ评估的和脂肪摄入量没有显示出与乳腺癌风险的统计学意义上的关联 (HR 1.10,p=0.23).
- 这些发现表明和脂肪和乳腺癌之间存在潜在的联系,FFQs无法检测到.
结论:
- 饮食测量误差,特别是来自FFQs,可能会掩盖饮食脂肪和乳腺癌风险之间的真实关系.
- 详细的饮食评估方法,如食物日记,可以更准确地了解饮食与癌症的关联.
- 重新评估饮食评估方法对于理解脂肪摄入量在乳腺癌发生中的作用至关重要.
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