在精神分裂症和双相情感障碍中,寡头细胞功能障碍.
Dmitri Tkachev1, Michael L Mimmack, Margaret M Ryan
1Department of Neurobiology, Babraham Institute, Cambridge, UK.
Lancet (London, England)
|September 19, 2003
概括
精神分裂症和双相情感障碍的大脑显示了小寡腺细胞和髓基因的减少表达. 这些发现表明,共同的途径有助于两种情况.
科学领域:
- 神经科学是一个神经科学.
- 遗传学 遗传学是一种遗传学.
- 精神病学是一个精神病学.
背景情况:
- 以前的阵列研究表明,在精神分裂症中,脂质和髓相关基因的异常表达.
- 寡细胞功能和髓化对大脑健康至关重要,并与精神疾病有关.
研究的目的:
- 研究在精神分裂症和双相情感障碍中特定于寡头细胞和髓化相关的基因表达.
- 为了比较精神分裂症,双相情感障碍和控制大脑之间的基因表达模式.
主要方法:
- 使用了来自斯坦利大脑收藏的脑样本 (15个精神分裂症,15个双相情感障碍,15个对照组).
- 采用基于索引的差异显示PCR用于基因表达差异的初始查.
- 验证了发现,并使用定量PCR和微阵列分析评估了16个额外的寡基因和髓基因.
主要成果:
- 与对照人群相比,在精神分裂症和双相情感障碍患者中,关键的寡类细胞相关和髓相关基因显著减少.
- 观察到精神分裂症和双相情感障碍之间的表达变化重叠的程度很高.
- 定量PCR和微阵列分析显示了研究基因的良好相关性.
结论:
- 精神分裂症和双相情感障碍的大脑表现出关键的寡干细胞和髓化基因的下调,包括调节性转录因子.
- 这些发现支持并扩展了以前基于微阵列的观测.
- 双极性障碍大脑中共享的基因表达变化表明精神分裂症的共同病理生理路径.
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