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相关概念视频

Olfaction01:25

Olfaction

40.5K
The sense of smell is achieved through the activities of the olfactory system. It starts when an airborne odorant enters the nasal cavity and reaches olfactory epithelium (OE). The OE is protected by a thin layer of mucus, which also serves the purpose of dissolving more complex compounds into simpler chemical odorants. The size of the OE and the density of sensory neurons varies among species; in humans, the OE is only about 9-10 cm2.
The olfactory receptors are embedded in the cilia of the...
40.5K
Olfactory Receptors: Location and Structure01:03

Olfactory Receptors: Location and Structure

10.6K
The process of olfaction, also known as the sense of smell, is a sophisticated chemical response system. The specialized sensory neurons that facilitate this process, known as olfactory receptor neurons, are situated in an upper segment of the nasal cavity, known as the olfactory epithelium. Olfactory sensory neurons are bipolar, with their dendrites extending from the epithelium's apex into the mucus that lines the nasal cavity. Airborne molecules, when inhaled, traverse the olfactory...
10.6K
Physiology of Smell and Olfactory Pathway01:20

Physiology of Smell and Olfactory Pathway

13.2K
Humans detect odors with the help of specialized cells located in the upper part of the nasal cavity, called olfactory receptor neurons (ORNs). ORNs possess hair-like structures called cilia, which are receptive to sensations from the inhaled air. When an odorant molecule binds to a specific receptor on the cell of the cilia, it leads to a series of events that ultimately cause the ORN to send electrical signals to the olfactory bulb in the brain through the olfactory nerves.
The olfactory...
13.2K

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相关实验视频

Updated: May 5, 2026

The Olfactory System as a Model to Study Axonal Growth Patterns and Morphology In Vivo
08:29

The Olfactory System as a Model to Study Axonal Growth Patterns and Morphology In Vivo

Published on: October 30, 2014

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在小鼠的嗅觉系统中,轴突分类为质细胞的上下文模型.

Paul Feinstein1, Peter Mombaerts

  • 1The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA. feinstp@rockefeller.edu

Cell
|June 10, 2004
PubMed
概括

气味受体 (ORs) 将嗅觉感官神经元 (OSN) 轴突引导到特定的淋巴细胞. ORs的氨基酸序列决定了OSN轴突的身份,通过同型相互作用影响它们的融合到质细胞中.

科学领域:

  • 神经科学是一个神经科学.
  • 分子生物学分子生物学
  • 遗传学 是一个遗传学.

背景情况:

  • 目前的模型还不能完全解释气味受体 (ORs) 如何引导嗅觉神经元 (OSN) 轴突到质细胞.
  • 了解这个过程对于破译嗅觉系统发育和功能机制至关重要.

研究的目的:

  • 调查嗅觉受体 (OR) 氨基酸序列在确定嗅觉神经元 (OSN) 轴突身份和指导中的作用.
  • 阐明ORs为轴突融合调解同型相互作用的分子机制.

主要方法:

  • 基因向小鼠,以创建特定的OR编码区域替代品和混合物.
  • 用M71和M72 OR基因操纵分析嗅球中的轴突向球粒的向.
  • 检查OR中自然存在的氨基酸多态性及其对轴突身份的影响.

主要成果:

  • ORs的氨基酸序列直接赋予OSN轴突的身份,使它们能够凝聚成质细胞.
  • 在M71和M72 OR基因之间交换编码区域,成功地将轴突重定向到相应的淋巴细胞.
  • 混合OR和自然发生的多态性揭示了质表型的光谱,表明了依赖上下文的轴突身份.
  • 关键的氨基酸残留物,主要是在跨膜领域,是这个过程的关键.

更多相关视频

Recording Temperature-induced Neuronal Activity through Monitoring Calcium Changes in the Olfactory Bulb of Xenopus laevis
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Recording Temperature-induced Neuronal Activity through Monitoring Calcium Changes in the Olfactory Bulb of Xenopus laevis

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Quadruple Immunostaining of the Olfactory Bulb for Visualization of Olfactory Sensory Axon Molecular Identity Codes
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Quadruple Immunostaining of the Olfactory Bulb for Visualization of Olfactory Sensory Axon Molecular Identity Codes

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相关实验视频

Last Updated: May 5, 2026

The Olfactory System as a Model to Study Axonal Growth Patterns and Morphology In Vivo
08:29

The Olfactory System as a Model to Study Axonal Growth Patterns and Morphology In Vivo

Published on: October 30, 2014

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Recording Temperature-induced Neuronal Activity through Monitoring Calcium Changes in the Olfactory Bulb of Xenopus laevis
11:08

Recording Temperature-induced Neuronal Activity through Monitoring Calcium Changes in the Olfactory Bulb of Xenopus laevis

Published on: June 3, 2016

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Quadruple Immunostaining of the Olfactory Bulb for Visualization of Olfactory Sensory Axon Molecular Identity Codes
06:32

Quadruple Immunostaining of the Olfactory Bulb for Visualization of Olfactory Sensory Axon Molecular Identity Codes

Published on: June 5, 2017

6.7K

结论:

  • ORs通过提供特定的轴突身份,在OSN轴突指导中发挥着关键作用.
  • 提出了一个上下文模型,其中ORs调解类似轴突之间的同型相互作用,以实现精确的准.
  • 这一发现促进了对嗅觉系统中神经电路形成的基础分子机制的理解.