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相关概念视频

Oxygen Transport in the Blood01:27

Oxygen Transport in the Blood

Hemoglobin (Hb) is a crucial molecule in the human body, consisting of four polypeptide chains, each bound to an iron-containing heme group. This unique structure enables hemoglobin to bind to oxygen, with each molecule capable of combining with four molecules of oxygen, leading to rapid and reversible oxygen loading. When fully loaded with oxygen, it is called oxyhemoglobin, while hemoglobin that has released oxygen is called reduced hemoglobin or deoxyhemoglobin. As hemoglobin binds oxygen,...
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
Blood Studies for Cardiovascular System III: Serum Lipid Profile01:25

Blood Studies for Cardiovascular System III: Serum Lipid Profile

Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
Myocarditis I: Introduction01:21

Myocarditis I: Introduction

Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations01:19

Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations

The pathophysiology of Acute Coronary Syndrome [ACD] involves several key processes:The main underlying cause of ACD is atherosclerosis, a chronic inflammatory disease characterized by the buildup of lipid-laden plaques within the coronary arteries.As the atherosclerotic plaque grows in the coronary artery, it may become unstable due to the formation of a lipid-rich core and a thin fibrous cap. Inflammatory cells within the plaque, such as macrophages, secrete enzymes that degrade the...

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Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
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在IIa型高胆固醇血清症中增加了血栓氧生物合成.

G Davì1, M Averna, I Catalano

  • 1Department of Medicine, University of Palermo School of Medicine, Italy.

Circulation
|May 1, 1992
PubMed
概括

血小板血栓素A2 (TXA2) 生物合成在IIa型高胆固醇血症中升高,与高胆固醇有关. 低剂量阿司匹林有效地减少TXA2代谢物分泌,表明TXA2依赖的血小板激活.

科学领域:

  • 心血管研究研究心血管研究
  • 生物化学 生物化学
  • 药理学 药理学是指药理学的学科.

背景情况:

  • 据报道,在IIa型高胆固醇血症中,血小板血素A2 (TXA2) 的产生增加.
  • 这项研究通过测量尿路代谢物来研究TXA2生产的体内相关性.

研究的目的:

  • 在IIa型高胆固醇血症中评估体内血栓素A2 (TXA2) 生物合成.
  • 为了将TXA2代谢物分泌与胆固醇水平和血小板功能相关联.
  • 为了评估simvastatin和阿司匹林对TXA2生产的影响.

主要方法:

  • 在46名高胆固醇血症患者和20名用放射性免疫检测测的对照组中测量了尿中的11-脱-TXB2和2,3-丁-TXB2.
  • 相关的代谢物分泌与原蛋白/阿拉基酸盐聚合值,体外血小板TXB2生产和血胆固醇.
  • 评估了simvastatin和低剂量阿司匹林对尿道TXA2代谢物的影响.

主要成果:

  • 在患者 (68.7 ng/hr) 和对照组 (22.4 ng/hr) 中,尿液中的11-脱-TXB2分泌量显著高于对照组 (22.4 ng/hr),其中74%的患者超过正常水平.
  • 排泄与血小板聚合灵敏度,体外TXB2产生和血总胆固醇相关.
  • 西姆瓦斯塔丁降低了胆固醇和TXA2代谢产物,但降低并没有相关性.

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Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
07:29

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LDL Cholesterol Uptake Assay Using Live Cell Imaging Analysis with Cell Health Monitoring
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LDL Cholesterol Uptake Assay Using Live Cell Imaging Analysis with Cell Health Monitoring

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Isolation and Analysis of Plasma Lipoproteins by Ultracentrifugation
06:47

Isolation and Analysis of Plasma Lipoproteins by Ultracentrifugation

Published on: January 28, 2021

  • 低剂量阿司匹林约70%抑制了11-脱-TXB2的分泌.

    • 结论:

    • 在大多数IIa型高胆固醇血症患者中,增强的TXA2生物合成发生.
    • 增加TXA2的产生部分是由于胆固醇水平异常.
    • 低剂量阿司匹林有效抑制TXA2代谢物分泌量的增加,在体内证实TXA2依赖性血小板激活.