Search research articles

关于 JoVE

概览领导团队博客 JoVE 帮助中心

作者

出版流程编辑委员会范围与政策同行评审常见问题投稿

图书馆员

用户评价订阅访问资源图书馆顾问委员会常见问题

研究

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments 存档

教育

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual 教师资源中心教师网站

使用条款与条件

相关概念视频

Three-Dimensional Microscopy in Microbiology

Three-Dimensional Microscopy in Microbiology

Three-dimensional imaging techniques are essential in cell biology, allowing researchers to visualize intricate cellular structures with high resolution. Two prominent methods, Differential Interference Contrast Microscopy (DIC) and Confocal Scanning Laser Microscopy (CSLM), provide distinct advantages for imaging live and thick specimens, respectively.Differential Interference Contrast MicroscopyDIC microscopy enhances contrast in transparent, unstained samples by converting phase...

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序

Same author

Evaluating possible treatment effect heterogeneity in a randomized trial of milrinone versus dobutamine in cardiogenic shock.

Critical care (London, England)·2026

Same author

Comparative Analysis of Streptozotocin, Streptozotocin-Nicotinamide and Alloxan-Based Diabetes Models in Female Wistar Rats.

Methods and protocols·2026

Same author

Synthesis and Characterization of ULK1/2 Kinase Inhibitors That Inhibit Autophagy and Upregulate Expression of Major Histocompatibility Complex I for the Treatment of Non-Small Cell Lung Cancer.

ACS chemical biology·2026

Same author

Synthesis and Characterization of ULK1/2 Kinase Inhibitors that Inhibit Autophagy and Upregulate Expression of Major Histocompatibility Complex I for the Treatment of Non-Small Cell Lung Cancer.

bioRxiv : the preprint server for biology·2025

Same author

Beyond the Basics: Exploring Pharmacokinetic Interactions and Safety in Tyrosine-Kinase Inhibitor Oral Therapy for Solid Tumors.

Pharmaceuticals (Basel, Switzerland)·2025

Same author

Exploring the Pharmacogenetic Landscape: Identification of Clinically Relevant Genotypes by a Nation-Wide Medical Testing Laboratory in Romania.

Pharmaceuticals (Basel, Switzerland)·2025

Search research articles

相关实验视频

Updated: Jul 5, 2026

Assaying Predatory Feeding Behaviors in Pristionchus and Other Nematodes

Assaying Predatory Feeding Behaviors in Pristionchus and Other Nematodes

Published on: September 4, 2016

线虫死亡机器在3D中

Cristina Pop¹, Guy S Salvesen

¹Program in Apoptosis and Cell Death Research, The Burnham Institute for Medical Research, La Jolla, California 92037, USA.

|October 22, 2005

概括

此摘要是机器生成的。

研究人员重建了虫亡途径的核心组成部分. 结构分析揭示了死亡激活剂CED-4是如何由抗瘤蛋白CED-9调节的,独立于ATP水解.

更多相关视频

Cultivation of Caenorhabditis elegans in Three Dimensions in the Laboratory

Cultivation of Caenorhabditis elegans in Three Dimensions in the Laboratory

Published on: December 12, 2016

High-Throughput Behavioral Aging and Lifespan Assays Using the Lifespan Machine

High-Throughput Behavioral Aging and Lifespan Assays Using the Lifespan Machine

Published on: January 26, 2024

相关实验视频

Last Updated: Jul 5, 2026

Assaying Predatory Feeding Behaviors in Pristionchus and Other Nematodes

Assaying Predatory Feeding Behaviors in Pristionchus and Other Nematodes

Published on: September 4, 2016

Cultivation of Caenorhabditis elegans in Three Dimensions in the Laboratory

Cultivation of Caenorhabditis elegans in Three Dimensions in the Laboratory

Published on: December 12, 2016

High-Throughput Behavioral Aging and Lifespan Assays Using the Lifespan Machine

High-Throughput Behavioral Aging and Lifespan Assays Using the Lifespan Machine

Published on: January 26, 2024

科学领域:

细胞生物学细胞生物学
发展生物学发展生物学
分子生物学分子生物学

背景情况:

调节的亡对于线虫Caenorhabditis elegans的发展至关重要.
了解细胞亡的分子机制是细胞生物学的基础.

研究的目的:

为了在体外复制C. elegans亡途径的核心成分.
阐明CED-9.0规范CED-4活动的结构基础.

主要方法:

核心亡途径组件的体外复制.
对CED-4/CED-9复合体的结构分析.

主要成果:

这项研究成功地重建了C. elegans的核心亡机制.
结构分析显示了CED-4和CED-9之间的相互作用,解释了CED-4法规.
一种AAA+ ATPase的CED-4似乎在没有ATP水解的情况下起作用.

结论:

这些发现提供了C. elegans中细胞亡调节的结构机制.
这项研究揭示了AAA+ ATPase的CED-4在编程细胞死亡中的独特功能.