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用于探测甘氨酸的化学技术

Jennifer A Prescher1, Carolyn R Bertozzi

  • 1Department of Chemistry, Howard Hughes Medical Institute, University of California, Berkeley, CA 94720, USA.

Cell
|September 9, 2006
PubMed
概括

化学工具正在出现,以帮助科学家了解甘氨酸在生物过程中的关键作用. 这些新技术克服了以前在分子水平上研究这些复杂碳水化合物的限制.

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Protein Glycosylation01:25

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Glycosylation, the most common post-translational modification for proteins, serves diverse functions. Adding sugars to proteins makes the proteins more resistant to proteolytic digestion. Glycosylated proteins can act as markers and receptors to promote cell-cell adhesion. Additionally, they have many essential quality control functions in the cell, such as correct protein folding and facilitating transport of misfolded proteins to the cytosol, which can be degraded.
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