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相关概念视频

Photoreceptors and Visual Pathways01:22

Photoreceptors and Visual Pathways

At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category, whereas...
The Retina01:32

The Retina

The retina is a layer of nervous tissue at the back of the eye that transduces light into neural signals. This process, called phototransduction, is carried out by rod and cone photoreceptor cells in the back of the retina.
Diabetic Retinopathy01:27

Diabetic Retinopathy

DefinitionDiabetic retinopathy is a microvascular complication of diabetes affecting the retinal blood vessels.Risk FactorsDiabetic retinopathy is present in almost all individuals with type 1 diabetes and more than 60% of those with type 2 diabetes after two decades of disease.The risk increases with poor glycemic control, hypertension, dyslipidemia, smoking, pregnancy, and puberty.Although cataracts and glaucoma are also more frequent in people with diabetes, retinopathy remains the leading...

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相关实验视频

Updated: Jul 18, 2026

Retinal Pigment Epithelium Transplantation in a Non-human Primate Model for Degenerative Retinal Diseases
11:20

Retinal Pigment Epithelium Transplantation in a Non-human Primate Model for Degenerative Retinal Diseases

Published on: June 14, 2021

视网膜色素炎 (Retinitis Pigmentosa) 是一种可见的疾病.

Dyonne T Hartong1, Eliot L Berson, Thaddeus P Dryja

  • 1Ocular Molecular Genetics Institute, Harvard Medical School, Massachusetts Eye and Ear Infirmary, 243 Charles Street, Boston, MA 02114, USA.

Lancet (London, England)
|November 23, 2006
PubMed
概括

视网膜色素炎 (retinitis pigmentosa) 是一组遗传性视网膜疾病,由于光受体细胞退化,导致逐渐失去视力. 营养干预措施对许多患者来说有望减缓疾病进展.

科学领域:

  • 眼科医生 眼科 眼科
  • 遗传学 遗传学 是一个
  • 分子生物学分子生物学

背景情况:

  • 遗传性视网膜退化是基因多样化的,已确定超过100个基因.
  • 皮质视网膜炎 (RP) 会导致杆状和状光受体的逐渐丧失,导致视力受损.
  • 视网膜功能在临床症状 (如夜盲或视力敏度下降) 显现之前的几年内可能会下降.

研究的目的:

  • 审查视网膜色素炎的遗传基础和临床进展.
  • 讨论当前对疾病机制和潜在治疗策略的理解.
  • 突出营养干预和RP新兴治疗方法的影响.

主要方法:

  • 对遗传研究,临床试验和与视网膜色素炎相关的生化途径分析的文献综述.
  • 对营养干预措施的受控试验结果的分析.
  • 对新发现的基因和动物模型的信息的综合.

主要成果:

  • 已经确定了45多个视网膜色素炎的基因,约占病例的60%.
  • 营养干预措施,包括维生素A棕酸和omega-3脂肪酸,在许多RP患者中,已经证明减缓了疾病进展.
  • 通过新的基因发现和动物模型的开发,了解RP的重大进展是显而易见的.

相关实验视频

Last Updated: Jul 18, 2026

Retinal Pigment Epithelium Transplantation in a Non-human Primate Model for Degenerative Retinal Diseases
11:20

Retinal Pigment Epithelium Transplantation in a Non-human Primate Model for Degenerative Retinal Diseases

Published on: June 14, 2021

结论:

  • 视网膜色素炎是一种复杂的遗传疾病,目前正在研究其原因和治疗方法.
  • 营养策略提供了一种可行的方法来控制疾病的进展.
  • 预计未来的治疗方法,特别是在基因定义的患者子组,由基因理解和治疗开发的进步驱动.