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相关概念视频

Protein Kinases and Phosphatases02:54

Protein Kinases and Phosphatases

Proteins undergo chemical modifications that trigger changes in the charge, structure, and conformation of the proteins. Phosphorylation, acetylation, glycosylation, nitrosylation, ubiquitination, lipidation, methylation, and proteolysis are various protein modifications that regulate protein activity. Such modifications are usually enzyme-driven.
Protein kinases
Many proteins in the cell are regulated by phosphorylation, the addition of a phosphate group. A family of enzymes called kinases...
Protein Kinases and Phosphatases02:54

Protein Kinases and Phosphatases

Proteins undergo chemical modifications that trigger changes in the charge, structure, and conformation of the proteins. Phosphorylation, acetylation, glycosylation, nitrosylation, ubiquitination, lipidation, methylation, and proteolysis are various protein modifications that regulate protein activity. Such modifications are usually enzyme-driven.
Protein kinases
Many proteins in the cell are regulated by phosphorylation, the addition of a phosphate group. A family of enzymes called kinases...
Phosphorylation01:02

Phosphorylation

The addition or removal of phosphate groups from proteins is the most common chemical modification that regulates cellular processes. These modifications can affect the structure, activity, stability, and localization of proteins within cells as well as their interactions with other proteins.
During phosphorylation, protein kinases transfer the terminal phosphate group of ATP to specific amino acid side chains of substrate proteins. Serine, threonine, and tyrosine are the most commonly...
Phosphorylation01:02

Phosphorylation

The addition or removal of phosphate groups from proteins is the most common chemical modification that regulates cellular processes. These modifications can affect the structure, activity, stability, and localization of proteins within cells as well as their interactions with other proteins.
During phosphorylation, protein kinases transfer the terminal phosphate group of ATP to specific amino acid side chains of substrate proteins. Serine, threonine, and tyrosine are the most commonly...
Calmodulin-dependent Signaling01:16

Calmodulin-dependent Signaling

Calmodulin (CaM) is a calcium-binding protein in eukaryotes that controls various calcium-regulated cellular processes. It has four calcium-binding sites that bind calcium to form the calcium-calmodulin ( Ca2+-CaM) complex. GPCR stimulation increases the calcium levels in the cells that bind to CaM and induces a conformational change.
The Ca2+-CaM complex does not have enzymatic activity by itself. Instead, the complex binds downstream target proteins, including membrane proteins or enzymes,...
Long-term Potentiation01:25

Long-term Potentiation

Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
Hebbian LTP
LTP can occur when presynaptic neurons...

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相关实验视频

Updated: Jul 14, 2026

Investigation of Synaptic Tagging/Capture and Cross-capture using Acute Hippocampal Slices from Rodents
11:29

Investigation of Synaptic Tagging/Capture and Cross-capture using Acute Hippocampal Slices from Rodents

Published on: September 4, 2015

酸盐介导的分子记忆由两个不同的蛋白激酶驱动,作为信息输入元素.

Kin-Ya Tomizaki1, Hisakazu Mihara

  • 1Department of Bioengineering and The COE21 Program, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, 4259 B-40 Nagatsuta, Midori, Yokohama, Japan. tomizaki@rite.or.jp

Journal of the American Chemical Society
|June 15, 2007
PubMed
概括

研究人员开发了一个分子记忆系统,使用一个执行布尔逻辑运算的酸. 这个系统通过酸化和脱酸化记录,存储,读取和删除信息,为分子计算铺平了道路.

科学领域:

  • 分子工程分子工程分子工程分子工程分子工程分子分子分子分子分子分子分子分子分子分子分子分子分子分子分子分子分子分子分子分子分子分子分子分子分子分子分子分子分子分子分子分子分子分子分子分子分子分子分子分子分子分子分子分子分子分子分子分子分子分子分子分子分子分子分子分子分子
  • 生物分子计算计算技术
  • 纳米技术 纳米技术

背景情况:

  • 对分子尺度设备的兴趣越来越大,用于布尔逻辑运算.
  • 以前的努力集中在分子逻辑门的化学,物理和生物输入.
  • 需要强大的分子记忆系统来处理信息.

研究的目的:

  • 设计和合成一种用于酸盐介导分子记忆的新型联蛋白激酶基质.
  • 使用这个分子系统来演示基本的逻辑运算 (AND,OR,NOR).
  • 探索基于分子的信息处理和计算的潜力.

主要方法:

  • 设计和合成具有两个可酸化区域和一个N终端螺旋衍生物的合.
  • 利用酶催化酸化来记录信息,使用酸酶催化去酸化来删除信息.
  • 用于用于信号读取和编程逻辑函数的离子聚合物的螺旋兰到美洛 (SP-to-MC) 热色变化.

主要成果:

  • 成功演示了基于酸化诱导的SP-to-MC热色变化的AND,OR和NOR逻辑运算.
  • 信息被稳定地存储为光体,并通过热着色进行阅读.

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Investigation of Synaptic Tagging/Capture and Cross-capture using Acute Hippocampal Slices from Rodents
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  • 该系统展示了记录,存储,读取和删除的完整循环.

    • 结论:

    • 开发的基于的系统作为酸盐介导的分子记忆功能.
    • 概念验证实验显示了基于分子的处理和计算的潜力.
    • 这项工作为开发实用的分子信息存储和处理设备提供了基础.