度作为生物膜模型中性识别的开关
Cecilia Bombelli1, Carlotta Bernardini, Gioia Elemento
1CNR, Istituto di Metodologie Chimiche and Dipartimento di Chimica "La Sapienza", P.le A. Moro 5, 00185 Roma, Italy.
Journal of the American Chemical Society
|February 9, 2008
概括
使用生物膜模型实现了状识别. 乙纯表面活性剂选择性丰富了胆红素,显示了可调整的刻板化学偏差在奇拉分离中.
科学领域:
- 生物膜模型 生物膜模型
- 超分子化学 超分子化学
- 希拉尔分离的分离方式
背景情况:
- 胆红素-IXalpha 是一种重要的生物分子,存在于一种种族混合物中.
- 在生物化学和药理学中,开发有效的性识别和分离方法至关重要.
- 生物仿真方法为模仿生物性识别过程提供了有希望的策略.
研究的目的:
- 为了研究生物膜模型中的奇拉识别能力.
- 探索特定表面活性剂在选择性转化中的潜力.
- 了解影响立体化学偏差和酶体丰富的因素.
主要方法:
- 使用基-N-基-N,N-二甲基-N-(1-基) 乙烯胺表面活性剂形成微粒聚合物.
- 用这些状聚合物化血细胞胆红素-IXalpha.
- 使用分析技术分析得到的混合物,以确定反体丰富度.
主要成果:
- 状聚合物表现出奇拉性识别,将血细胞胆红素-IXalpha转化为一种基丰富的混合物.
- 富度和立体化学偏好程度取决于表面活性剂的疏水性和度.
- 观察到的立体化学偏差的变化是可逆的,这表明对性识别过程的动态控制.
结论:
- 能有效地在生物膜模型中进行奇拉性识别的化乙烯基 (N-alkyl-N,N-dimethyl-N-(1-phenyl) 乙烯基胺表面活性剂.
- 该系统提供可调和可逆的控制对比利鲁-IXalpha的酶体丰富.
- 这项研究突出了定制的超分子组件的潜力,用于奇拉分辨率应用.
相关概念视频
Prochirality
The concept of prochirality leads to the nomenclature of the individual faces of a molecule and plays a crucial role in the enantioselective reaction. It is a concept where two or more achiral molecules react to produce chiral products. A typical process is the reaction of an achiral ketone to generate a chiral alcohol. Here, the achiral reactant reacts with an achiral reducing agent, sodium borohydride, to generate an equimolar mixture of the chiral enantiomers of the product. For example, an...
Chirality in Nature
Chirality is the most intriguing yet essential facet of nature, governing life’s biochemical processes and precision. It can be observed from a snail shell pattern in a macroscopic world to an amino acid, the minutest building block of life. Most of the snails around the world have right-coiled shells because of the intrinsic chirality in their genes. All the amino acids present in the human body exist in an enantiomerically pure state, except for glycine - the sole achiral amino acid. The...
Molecules with Multiple Chiral Centers
Molecules that possess multiple chiral centers can afford a large number of stereoisomers. For instance, while some molecules like 2-butanol have one chiral center, defined as a tetrahedral carbon atom with four different substituents attached, several molecules like butane-2,3-diol have multiple chiral centers. A simple formula to predict the number of stereoisomers possible for a molecule with n chiral centers is 2n. However, there can be a lower number where some of the stereoisomers are...
Chirality
Chirality is a term that describes the lack of mirror symmetry in an object. In other words, chiral objects cannot be superposed on their mirror images. For example, our feet are chiral, as the mirror image of the left foot, the right foot, cannot be superposed on the left foot.
Chiral objects exhibit a sense of handedness when they interact with another chiral object. For example, our left foot can only fit in the left shoe and not in the right shoe. Achiral objects — objects that have...
Chiral objects exhibit a sense of handedness when they interact with another chiral object. For example, our left foot can only fit in the left shoe and not in the right shoe. Achiral objects — objects that have...
Chirality at Nitrogen, Phosphorus, and Sulfur
Chirality is most prevalent in carbon-based tetrahedral compounds, but this important facet of molecular symmetry extends to sp3-hybridized nitrogen, phosphorus and sulfur centers, including trivalent molecules with lone pairs. Here, the lone pair behaves as a functional group in addition to the other three substituents to form an analogous tetrahedral center that can be chiral.
A consequence of chirality is the need for enantiomeric resolution. While this is theoretically possible for all...
A consequence of chirality is the need for enantiomeric resolution. While this is theoretically possible for all...
Properties of Enantiomers and Optical Activity
It is essential to understand the difference between chiral and achiral interactions and the implications thereof in optical activity and their applications. Just as our feet, which are chiral, interact uniquely with chiral objects, such as a pair of shoes, but identically with achiral socks, enantiomers of a molecule exhibit different properties only when they interact with other chiral media. An example of a significant implication from this facet is the phenomenon known as optical activity,...


