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相关概念视频

Embryonic Stem Cells00:58

Embryonic Stem Cells

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Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
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Commitment is the  process whereby stem cells:
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The development of all multicellular organisms starts with the fusion of haploid cells called sperm and egg to form a diploid zygote. A zygote is a totipotent cell that can develop into a complete organism. The zygote undergoes cell division or cleavage to form an 8-cell mass. Until this stage, the cells are spherical, loosely attached, and remain totipotent. Totipotent cells are capable of developing both the embryonic and the extraembryonic tissues. However, as they continue to divide, they...
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Source And Potency Of Stem Cells01:27

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Stem cells are undifferentiated cells with extensive self-renewal properties that help them maintain their population during the fetal and adult stages of life. They can specialize in all cell types of the human body. However, their differential potential may vary and can be classified into five types. Stem cells can be (1) Totipotent, (2) Pluripotent, (3) Multipotent, (4) Oligopotent, and (5) Unipotent. Each stem cell has a specific origin; the fertilized egg or zygote is a totipotent cell and...
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Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
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Embryonic Stem Cells00:57

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Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
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Quantitative Analysis of Protein Expression to Study Lineage Specification in Mouse Preimplantation Embryos
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Quantitative Analysis of Protein Expression to Study Lineage Specification in Mouse Preimplantation Embryos

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干细胞和早期的血统发展.

Janet Rossant1

  • 1Program in Developmental and Stem Cell Biology, Hospital for Sick Children Research Institute, Department of Molecular Genetics, University of Toronto, 555 University Avenue, Toronto, ON, M5G 1X8, Canada. janet.rossant@sickkids.ca

Cell
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概括
此摘要是机器生成的。

来自各种来源的新的多能干细胞系,包括成人细胞,呈现出不同的发育状态. 了解这些状态对于指导干细胞分化用于治疗应用至关重要.

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科学领域:

  • 干细胞生物学 干细胞生物学
  • 发育生物学是发展生物学.
  • 再生医学是一种再生医学.

背景情况:

  • 多能干细胞系可以从多个来源获得,包括重新编程的成年体细胞.
  • 干细胞的分化潜力受其发育起源的影响.
  • 已经确定了两种不同的多能状态,即表皮质细胞和胃化原体.

研究的目的:

  • 为了研究各种多能干细胞状态的发育等价性.
  • 了解不同多能系的初始发育状态.
  • 定义治疗细胞分化的最佳起始条件.

主要方法:

  • 来自不同来源的多能干细胞系的衍生.
  • 显著的多能状态的特征.
  • 对发展潜力的比较分析.

主要成果:

  • 多能干细胞系至少表现出两个不同的发育状态.
  • 这些状态对应于表皮质原始体和后来的胃化胚胎原始体.
  • 初始发育状态的变化影响差异化潜力.

结论:

  • 不同多能干细胞状态的发育等价性是一个关键考虑因素.
  • 了解多能细胞的初始状态对于有针对性的分化至关重要.
  • 这种知识对于推进基于干细胞的疗法至关重要.