评论"在发育增强剂中获得人类特异性的功能增强"
Laurent Duret1, Nicolas Galtier
1Université de Lyon, Université Lyon 1, CNRS, UMR5558, Laboratoire de Biométrie et Biologie Evolutive, F-69622, Villeurbanne, France. duret@biomserv.univ-lyon1.fr
概括
人类特异性序列HACNS1显示中性进化,而不是积极选择. 它的功能变化很可能是由于偏向的基因转换而产生的,而不是适应.
科学领域:
- 进化生物学是进化的生物学.
- 人类遗传学 人类遗传学
- 分子进化是分子进化的过程.
背景情况:
- 保存的非编码序列HACNS1此前被提议在积极选择下,推动人类的适应.
- 这种假设是基于在HACNS1.1中观察到的替代模式.
相关概念视频
In-vitro Mutagenesis
To learn more about the function of a gene, researchers can observe what happens when the gene is inactivated or “knocked out,” by creating genetically engineered knockout animals. Knockout mice have been particularly useful as models for human diseases such as cancer, Parkinson’s disease, and diabetes.
Transgenic Organisms
Overview
Transgenic Organisms
Overview
Conservative Site-specific Recombination and Phase Variation
Because the DNA segments are cut and reorganized in a direction-specific manner, site-specific recombination has emerged as an efficient genetic engineering technique. Flippase and Cyclization recombinases or Flp and Cre, respectively, are two members of the tyrosine recombinase family derived from bacteriophages, that are used to mediate site-specific DNA insertions, deletions, and targeted expression of proteins in mammalian cell lines.
The recognition sites for Cre recombinase called LoxP...
The recognition sites for Cre recombinase called LoxP...

