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相关概念视频

Protein Dynamics in Living Cells01:19

Protein Dynamics in Living Cells

Different fluorescence-based techniques are used to study the protein dynamics in living cells. These techniques include FRAP, FRET, and PET.
Fluorescent recovery after photobleaching (FRAP) is a fluorescent-protein-based detection technique used to quantify protein movement rates within the cell. This method exposes a small portion of the cell to an intense laser beam. The laser beam causes permanent photobleaching of the fluorophore-tagged proteins in the exposed region. As the bleached...
Evolution of New Traits in Microbes01:24

Evolution of New Traits in Microbes

Microorganisms evolve rapidly due to their large population sizes and short generation times, often exhibiting measurable changes within days under laboratory conditions. Natural selection acts on standing genetic variation, enabling the retention and amplification of beneficial traits that confer fitness advantages in changing environments.Adaptive Pigment Regulation in RhodobacterIn Rhodobacter, a genus of purple non-sulfur bacteria, light-harvesting pigments such as bacteriochlorophyll and...
Mechanical Protein Functions01:58

Mechanical Protein Functions

Proteins perform many mechanical functions in a cell. These proteins can be classified into two general categories- proteins that generate mechanical forces and proteins that are subjected to mechanical forces. Proteins providing mechanical support to the structure of the cell, such as keratin, are subjected to mechanical force, whereas proteins involved in cell movement and transport of molecules across cell membranes, such as an ion pump, are examples of generating mechanical force. 
Gene Evolution - Fast or Slow?02:05

Gene Evolution - Fast or Slow?

The genomes of eukaryotes are punctuated by long stretches of sequence which do not code for proteins or RNAs. Although some of these regions do contain crucial regulatory sequences, the vast majority of this DNA serves no known function. Typically, these regions of the genome are the ones in which the fastest change, in evolutionary terms, is observed, because there is typically little to no selection pressure acting on these regions to preserve their sequences.
In contrast, regions which code...
Gene Evolution - Fast or Slow?02:05

Gene Evolution - Fast or Slow?

The genomes of eukaryotes are punctuated by long stretches of sequence which do not code for proteins or RNAs. Although some of these regions do contain crucial regulatory sequences, the vast majority of this DNA serves no known function. Typically, these regions of the genome are the ones in which the fastest change, in evolutionary terms, is observed, because there is typically little to no selection pressure acting on these regions to preserve their sequences.
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The cytoskeleton is a complex dynamic structure performing varied functions based on cellular requirements. The adaptability of the individual filaments in the cytoskeleton determines their ability to perform various functions within the cell. It can undergo rapid reorganization during processes like cell division or remain stable for several hours as in the interphase. The adaptability of these filaments depends on stringent regulatory mechanisms. The microfilament and microtubules of the...

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Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web
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Published on: July 16, 2017

蛋白质的活力和可进化的能力.

Nobuhiko Tokuriki1, Dan S Tawfik

  • 1Department of Biological Chemistry, Weizmann Institute of Science, Rehovot 76100, Israel.

Science (New York, N.Y.)
|April 11, 2009
PubMed
概括
此摘要是机器生成的。

蛋白质是动态和适应性的,而不是固定的. 这种灵活性和功能性乱交是蛋白质进化的关键,使新功能和结构成为可能.

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科学领域:

  • 生物化学 生物化学
  • 分子生物学分子生物学
  • 进化生物学 进化生物学

背景情况:

  • 传统观点:蛋白质具有固定的结构和特定的功能.
  • 观察:蛋白质表现出显著的适应性和新功能/结构的演变.
  • 冲突:固定结构/功能模型与观察到的蛋白质可塑性.

研究的目的:

  • 提出蛋白质结构和功能的另一种"先观点".
  • 探索蛋白质动态性和功能性乱交在蛋白质可变性中的作用.
  • 研究蛋白质包装对进化能力的影响.

主要方法:

  • 基于现有文献的概念框架开发.
  • 分析蛋白质结构动力学和功能性乱交.
  • 将动态原理推断到早期的蛋白质进化和未来的研究.

主要成果:

  • 蛋白质在形状上是动态的,在功能上是杂乱的.
  • 这些特性是蛋白质可进化的基础.
  • 包装不良和无序的蛋白质表现出更高的进化性.
  • 动态视图有助于理解新的功能/折叠演变.

结论:

  • 蛋白质动态和功能性乱交是蛋白质进化的核心.
  • 了解蛋白质动态对于预测进化轨迹至关重要.
  • 未来的研究应该专注于蛋白质动态及其进化影响.