胃潰瘍疾病 胃潰瘍疾病
Peter Malfertheiner1, Francis K L Chan, Kenneth E L McColl
1Department of Gastroenterology, Hepatology, and Infectious Diseases, Otto-von-Guericke University, Magdeburg, Germany. peter.malfertheiner@med.ovgu.de
Lancet (London, England)
|August 18, 2009
概括
由于酸性抑制剂和Helicobacter pylori治疗的进步,胃潰瘍疾病的发生率有所降低. 然而,非类固醇抗炎药物 (NSAID) 和阿司匹林仍然会引起,需要持续的治疗策略.
科学领域:
- 胃肠病学 胃肠病学
- 流行病学 流行病学
- 药理学 药理学是指药理学的学科.
背景情况:
- 胃潰瘍病在歷史上造成了顯著的發病率和死亡率.
- 近几十年来,胃病发病率明显下降.
- 关键因素包括强大的抑制酸性药物和发现Helicobacter pylori.
研究的目的:
- 审查过去25年来理解和管理胃潰瘍疾病的革命.
- 研究非类固醇抗炎药物 (NSAID) 和低剂量阿司匹林对病的影响.
- 讨论药物诱导的和H.pylori阴性,NSAID阴性的策略.
主要方法:
- 对胃病的流行病学趋势的审查.
- 分析Helicobacter pylori发现对疾病理解和治疗的影响.
- 检查NSAIDs和阿司匹林在当前病原发生中的作用.
- 讨论药物引起的的治疗和预防策略.
主要成果:
- 胃病率的显著下降归因于酸性抑制剂和H. pylori根除.
- 非类固醇抗炎药物 (NSAID) 和低剂量阿司匹林现在是胃潰瘍的主要原因.
- H. pylori 阴性,NSAID 阴性是一种罕见但日益增长的临床挑战.
结论:
- 医学的进步已经改变了胃潰瘍疾病的管理.
- NSAID 和阿司匹林的使用继续推动病,需要有针对性的预防和治疗.
- 需要进一步的研究来管理复杂的病例,包括H. pylori阴性,NSAID阴性.
相关概念视频
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