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相关概念视频

Circadian Rhythms and Gene Regulation02:19

Circadian Rhythms and Gene Regulation

The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent years,...
Biological Clocks and Seasonal Responses02:45

Biological Clocks and Seasonal Responses

The circadian—or biological—clock is an intrinsic, timekeeping, molecular mechanism that allows plants to coordinate physiological activities over 24-hour cycles called circadian rhythms. Photoperiodism is a collective term for the biological responses of plants to variations in the relative lengths of dark and light periods. The period of light-exposure is called the photoperiod.

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相关实验视频

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Monitoring Cell-autonomous Circadian Clock Rhythms of Gene Expression Using Luciferase Bioluminescence Reporters
10:38

Monitoring Cell-autonomous Circadian Clock Rhythms of Gene Expression Using Luciferase Bioluminescence Reporters

Published on: September 27, 2012

pH时钟操作的机械化纳米粒子

Sarah Angelos1, Niveen M Khashab, Ying-Wei Yang

  • 1Department of Chemistry and Biochemistry, University of California, Los Angeles, California 90095, USA.

Journal of the American Chemical Society
|August 27, 2009
PubMed
概括

具有pH激活分子机器的机械化纳米粒子可控制地释放封装分子. 这些超分子系统根据环境pH值变化,精确控制客分子的传递.

科学领域:

  • 超分子化学 超分子化学
  • 纳米技术 纳米技术
  • 材料科学是一种材料科学.

背景情况:

  • 半孔纳米粒子 (MSNPs) 广泛用于药物输送.
  • 从纳米颗粒中控制封装分子的释放仍然是一个挑战.
  • 超分子化学为设计响应性分子系统提供了工具.

研究的目的:

  • 开发适应pH的机械化纳米粒子 (MNPs),用于控制分子释放.
  • 设计能够响应特定pH触发的超分子机器.
  • 为了证明在不同的pH条件下,从MNP中控制释放客分子.

主要方法:

  • 用超分子机器功能化的中孔纳米颗粒的合成.
  • 在纳米粒子表面设计和化学修改基于库库比特[6]乌里尔 (CB[6]) 的分子机器.
  • 使用发光光谱学来监测客分子的封装和释放.
  • 在各种pH条件下测试MNP性能.

主要成果:

  • 成功地将超分子机器集成到MSNP上,形成MNP.
  • 证明了对客分子封装和释放的pH依赖控制.
  • 在中性的pH值下,MNP有效地保留了客分子,并在pH值变化时释放它们.

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Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures
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Monitoring Cell-autonomous Circadian Clock Rhythms of Gene Expression Using Luciferase Bioluminescence Reporters
10:38

Monitoring Cell-autonomous Circadian Clock Rhythms of Gene Expression Using Luciferase Bioluminescence Reporters

Published on: September 27, 2012

Rapid Analysis of Circadian Phenotypes in Arabidopsis Protoplasts Transfected with a Luminescent Clock Reporter
07:42

Rapid Analysis of Circadian Phenotypes in Arabidopsis Protoplasts Transfected with a Luminescent Clock Reporter

Published on: September 17, 2016

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures
06:53

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures

Published on: November 11, 2016

  • 发光光谱学证实了触发的释放机制.

    • 结论:

    • 机械化纳米粒子为pH触发分子释放提供了一个强大的平台.
    • 开发的超分子机器提供可调和可控制的释放功能.
    • 这些MNP显示出需要精确输送封装物质的应用的潜力.