通过视觉体验在快速升的GABA电路中的双向可塑性.
Yoko Yazaki-Sugiyama1, Siu Kang, Hideyuki Câteau
1CREST, JST, Toyonaka, Osaka 560-0082, Japan.
Nature
|November 13, 2009
概括
大脑的可塑性依赖于平衡的激发和抑制. 这项研究揭示了抑制神经元最初有利于被剥夺的眼睛,然后是开放的眼睛,影响视觉皮层的发育.
科学领域:
- 神经科学是一个神经科学.
- 神经生物学 神经生物学 神经生物学
- 发育神经科学的发展神经科学.
背景情况:
- 经验依赖的大脑可塑性对发育至关重要.
- 平衡的激发和抑制是神经可塑性所必需的.
- 特定神经回路在可塑性中的作用仍然不清楚.
研究的目的:
- 调查单个电路元件对眼主导可塑性的贡献.
- 在视觉剥夺期间分析快速升细胞的体内细胞活动.
- 了解视觉皮层发育期间抑制电路的动态变化.
主要方法:
- 在未成年小鼠中从快速增长的细胞中体内细胞内记录.
- 眼睛主导性可塑性是由视觉剥夺引起的.
- 细胞内药理学被用来评估GABAergic对金字塔细胞的影响.
主要成果:
- 快速增长的细胞初步转向闭眼,随后晚期偏向开眼.
- 这种模式与抑制神经元的尖峰时间依赖的可塑性规则相一致.
- 在GABA (氨酸) 对金字塔细胞的影响中的动态切换仅在幼小小鼠中观察到.
结论:
- 最初双眼GABAergic电路的双向招募可能是经验依赖可塑性的基础.
- 抑制性内部神经元在视觉皮层可塑性中发挥着动态和反直觉的作用.
- 了解这些机制是理解视觉发育和潜在治疗干预的关键.
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