在链接位置的选择塑造了C. elegans遗传的表型变异
Matthew V Rockman1, Sonja S Skrovanek, Leonid Kruglyak
1Department of Biology and Center for Genomics and Systems Biology, New York University, 100 Washington Square East, New York, NY 10003, USA. mrockman@nyu.edu
Science (New York, N.Y.)
|October 16, 2010
概括
遗传变异是由突变引起的,是由遗传漂移和自然选择塑造的. 在Caenorhabditis elegans中,特征变异更多地受到区域有效种群大小的影响,而不是特征特异性因素.
科学领域:
- 遗传学 是一个遗传学.
- 进化生物学 进化生物学
- 分子生物学分子生物学
背景情况:
- 可遗传的变异是由突变产生的,然后由遗传漂移和自然选择对其起作用.
- 经典的定量遗传模型假设漂移在特征中是统一的,而突变和选择是特征特异的.
研究的目的:
- 调查影响量化特征位点 (QTLs) 在Caenorhabditis elegans中转录丰度分布的因素.
- 为了确定特征特异性突变/选择或特征独立因素是否更好地解释观察到的QTL模式.
主要方法:
- 在两个Caenorhabditis elegans菌株之间的交叉中确定了与转录丰度特征相关的数千个QTLs.
- 分析了与突变,选择和遗传漂移有关的这些QTL的分布模式.
- 对比了特征特异与特征独立的QTL分布模型的解释力.
主要成果:
- 虽然特征特异性突变和选择有助于QTL分布模式,但它们不是主要的驱动因素.
- 在链接站点上选择强度的特征独立变化为观察到的QTL分布提供了更好的解释.
- 具有不同有效种群大小的基因组区域显著影响了C. elegans的特征变异.
结论:
- 在C. elegans的不同特征中观察到的变异在很大程度上取决于基因组区域的有效种群大小,这些基因组区域包含它们的底层位置.
- 与区域有效人口大小相比,特征属性本身在确定变化水平方面的影响力较小.
- 这一发现完善了我们对遗传漂移和自然选择如何相互作用以塑造表型变异的理解.
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