Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

The Cell Cycle Control System01:28

The Cell Cycle Control System

The cell cycle regulation directs how a cell proceeds from one phase to the next and begins mitosis. The cell cycle control system includes intracellular regulatory molecules and external triggers. They provide "stop" or "advance" signals and operate at specific cell cycle stages termed checkpoints to ensure that a particular process is completed before the cell advances to the next phase.
Cyclins and cyclin-dependent kinases (Cdks) are the primary cell cycle regulators and function at the cell...
The Cell Cycle Control System02:11

The Cell Cycle Control System

The cell cycle is an organized set of events that leads the cell to divide into two daughter cells, each containing chromosomes identical to the parent cell. It is the cell cycle that leads to the formation of an entire organism from a single-cell zygote. Besides, cell division also functions in the renewal or repair of tissues in adult multicellular eukaryotes. For example, in the bone marrow, the stem cells divide to form new blood cells. Although essential for several functions, cell...
The Cell Cycle Control System02:11

The Cell Cycle Control System

The cell cycle is an organized set of events that leads the cell to divide into two daughter cells, each containing chromosomes identical to the parent cell. It is the cell cycle that leads to the formation of an entire organism from a single-cell zygote. Besides, cell division also functions in the renewal or repair of tissues in adult multicellular eukaryotes. For example, in the bone marrow, the stem cells divide to form new blood cells. Although essential for several functions, cell...
Molecular Factors Affecting Cell Division01:27

Molecular Factors Affecting Cell Division

Several external and internal factors influence the initiation and inhibition of cell division. For instance, the death of nearby cells or the release of human growth hormone (hGH) promotes cell division. In contrast, lack of hGH or crowding of cells can inhibit cell division.
Several proteins function as internal regulators to ensure each cell cycle stage is completed faithfully before proceeding to the next. Regulator molecules may act directly or influence the activity or production of other...
Positive Regulator Molecules01:45

Positive Regulator Molecules

To consistently produce healthy cells, the cell cycle—the process that generates daughter cells—must be precisely regulated.
Positive Regulator Molecules02:39

Positive Regulator Molecules

Mitotic cell division results in daughter cells that exactly resemble the parent cell. However, errors in the DNA replication or distribution of genetic material may lead to genetic mutations that may be passed down to every new cell formed from the resulting abnormal cell. Propagation of such mutant cells is restricted through checkpoint mechanisms present at different stages of the cell cycle. These checkpoints involve regulator molecules that either promote or demote cell cycle events.

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Global trends in human birth and death seasonality reveal climate-related shifts in reproductive timing.

bioRxiv : the preprint server for biology·2026
Same author

How does cytoplasmic crowding affect reaction rates?

Molecular cell·2025
Same author

Geometrical compartmentalization of trigger waves.

Proceedings of the National Academy of Sciences of the United States of America·2025
Same author

Mechanistic origins of temperature scaling in the early embryonic cell cycle.

Nature communications·2025
Same author

Mouse lemur cell atlas informs primate genes, physiology and disease.

Nature·2025
Same author

A molecular cell atlas of mouse lemur, an emerging model primate.

Nature·2025
Same journal

A viral ORFeome library for systems-level genetic dissection of host-pathogen interactions.

Cell·2026
Same journal

Co-option of lysosomal machinery shapes the evolution of the intracellular photosymbiosis supporting coral reefs.

Cell·2026
Same journal

LEF1 and niche factors determine T cell stemness across chronic diseases.

Cell·2026
Same journal

Recurrent patterns of TOP1-mediated neuronal genomic damage shared by major neurodegenerative disorders.

Cell·2026
Same journal

Four-dimensional molecular mapping from a spatial snapshot reveals the dynamics of hair follicle organogenesis.

Cell·2026
Same journal

Whole-cell particle-based digital twin simulations from 4D lattice light-sheet microscopy data.

Cell·2026
查看所有相关文章

相关实验视频

Updated: Jun 3, 2026

Reconstitution of Cell-cycle Oscillations in Microemulsions of Cell-free Xenopus Egg Extracts
06:31

Reconstitution of Cell-cycle Oscillations in Microemulsions of Cell-free Xenopus Egg Extracts

Published on: September 27, 2018

模拟细胞循环:为什么某些电路会振荡?

James E Ferrell1, Tony Yu-Chen Tsai, Qiong Yang

  • 1Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA 94305-5174, USA. james.ferrell@stanford.edu

Cell
|March 19, 2011
PubMed
概括
此摘要是机器生成的。

计算建模解释了真核细胞周期作为自主振荡器. 本研究详细介绍了振荡生物化学电路,重点是普通微分方程 (ODE) 模型和Xenopus胚胎细胞周期的稳定性分析.

更多相关视频

Alignment of Synchronized Time-Series Data Using the Characterizing Loss of Cell Cycle Synchrony Model for Cross-Experiment Comparisons
07:59

Alignment of Synchronized Time-Series Data Using the Characterizing Loss of Cell Cycle Synchrony Model for Cross-Experiment Comparisons

Published on: June 9, 2023

Manipulation and Analysis of Cell Cycle-Dependent Processes in Budding Yeast
08:13

Manipulation and Analysis of Cell Cycle-Dependent Processes in Budding Yeast

Published on: September 26, 2025

相关实验视频

Last Updated: Jun 3, 2026

Reconstitution of Cell-cycle Oscillations in Microemulsions of Cell-free Xenopus Egg Extracts
06:31

Reconstitution of Cell-cycle Oscillations in Microemulsions of Cell-free Xenopus Egg Extracts

Published on: September 27, 2018

Alignment of Synchronized Time-Series Data Using the Characterizing Loss of Cell Cycle Synchrony Model for Cross-Experiment Comparisons
07:59

Alignment of Synchronized Time-Series Data Using the Characterizing Loss of Cell Cycle Synchrony Model for Cross-Experiment Comparisons

Published on: June 9, 2023

Manipulation and Analysis of Cell Cycle-Dependent Processes in Budding Yeast
08:13

Manipulation and Analysis of Cell Cycle-Dependent Processes in Budding Yeast

Published on: September 26, 2025

科学领域:

  • 生物化学 生物化学
  • 系统生物学 系统生物学
  • 计算生物学 计算生物学

背景情况:

  • 细胞细胞周期,特别是在Xenopus胚胎中,表现出振荡行为.
  • 了解底层机制需要先进的理论框架超出简单的描述.

研究的目的:

  • 提出振荡生物化学电路的基本理论.
  • 使用计算模型阐明了Xenopus胚胎细胞周期的规律.

主要方法:

  • 检查布尔模型,延迟微分方程模型和普通微分方程 (ODE) 模型.
  • 在ODE模型中分析负反循环和合的正/负反电路.
  • 应用线性稳定性分析来预测基于动力参数的振荡行为.

主要成果:

  • 展示了简单的反回路如何在ODE模型中产生振荡.
  • 在细胞周期模型中确定持续振荡所需的条件.
  • 验证ODE模型以捕捉Xenopus胚胎细胞周期的动态.

结论:

  • 计算建模和非线性动态系统理论为细胞循环机制提供了深入的见解.
  • 振荡式生物化学电路对于细胞周期的自主运行至关重要.
  • 线性稳定性分析是验证和理解生物振荡器动态模型的关键工具.