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光小分子探测器用于调制和探索α2β1整合素功能.

Jarkko T Koivunen1, Liisa Nissinen, Jarmo Käpylä

  • 1Computational Bioscience Laboratory, Department of Biological and Environmental Science, University of Jyväskylä, Finland.

Journal of the American Chemical Society
|August 26, 2011
PubMed
概括

研究人员开发了一种新的光分子,可以阻止α2β1整合素和原蛋白之间的相互作用. 这一发现为针对癌症和血栓形成等疾病的治疗剂提供了新的可能性.

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Protein Dynamics in Living Cells01:19

Protein Dynamics in Living Cells

Different fluorescence-based techniques are used to study the protein dynamics in living cells. These techniques include FRAP, FRET, and PET.
Fluorescent recovery after photobleaching (FRAP) is a fluorescent-protein-based detection technique used to quantify protein movement rates within the cell. This method exposes a small portion of the cell to an intense laser beam. The laser beam causes permanent photobleaching of the fluorophore-tagged proteins in the exposed region. As the bleached...