纳米粒子的疏水性决定了免疫反应的发生
Daniel F Moyano1, Meir Goldsmith, David J Solfiell
1Department of Chemistry, University of Massachusetts, 710 North Pleasant Street, Amherst, Massachusetts 01003, USA.
Journal of the American Chemical Society
|February 21, 2012
概括
工程黄金纳米颗粒的疏水性直接影响免疫系统的激活. 在体外和体外研究中,增加的疏水性线性相关于更大的免疫活性,指导未来的纳米材料设计.
科学领域:
- 纳米医学是一种纳米医学.
- 免疫学 免疫学 免疫学
- 材料科学 材料科学 材料科学
背景情况:
- 了解纳米材料与免疫系统的相互作用对于开发体内应用至关重要.
- 通过复杂的宏分子探针研究免疫激活是具有挑战性的.
研究的目的:
- 用工程黄金纳米颗粒来隔离和研究疏水性对免疫反应的影响.
- 建立纳米粒子疏水性和免疫激活之间的定量关系.
主要方法:
- 合成了具有不同疏水性的工程黄金纳米粒子.
- 分析了脊髓细胞中细胞因子的基因表达特征.
- 在体外评估了水性 (log P) 和细胞因子表达之间的相关性.
- 在体外小鼠模型被用来验证体外发现.
主要成果:
- 观察到免疫活动的线性增加,随着黄金纳米颗粒群体的水性增加,在体外.
- 水性和免疫反应之间的这种相关性在体内是一致的.
- 疏水性被确定为通过纳米材料激活免疫系统的关键决定因素.
结论:
- 厌水性是调节对金纳米颗粒的免疫反应的一个关键因素.
- 这一发现为设计更安全,更有效的纳米材料在体内应用提供了一个设计原则.
- 未来的研究应该考虑疏水性作为纳米材料免疫毒性评估的主要参数.
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